Premature Ovarian Insufficiency Treatment with Human Mesenchymal Stem Cells: a Review Article

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Javanshir Reza; Salimnejad Ramin; Golmohammadi Mohammad Ghasem; Kalarestaghy Hossein

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Journal Paper

Paper Information

Journal: Journal of Ardabil University of Medical Sciences Year:2023 | Volume:23 | Issue:2 Page(s): 111-125

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Information Journal Paper

Title

Premature Ovarian Insufficiency Treatment with Human Mesenchymal Stem Cells: a Review Article

Author(s)

Javanshir Reza | Salimnejad Ramin | Golmohammadi Mohammad Ghasem | Kalarestaghy Hossein | Issue Writer Certificate

Keywords

Mesenchymal Stem CellQ4

Premature Ovarian InsufficiencyQ4

InfertilityQ4

Abstract

2Premature Ovarian Insufficiency (POI) refers to the loss of ovarian function before the age of 40. This condition can be attributed to various factors including X chromosome abnormalities, autoimmune disorders, and chemotherapy drugs. Hormone therapy is a commonly used treatment for POI, but due to side effects and low fertility rates, alternative treatment options are needed. In recent years, stem cell transplantation has emerged as a promising treatment approach, offering hope for improving and restoring ovarian function. Stem cells possess the unique ability of self-renewal and regeneration, making them potentially effective in addressing ovarian failure and subsequent Infertility. Different types of stem cells have been investigated for the treatment of POI, including Mesenchymal Stem Cells (MSCs), stem cells from extraembryonic tissues, induced pluripotent stem cells (iPSCs), and ovarian stem cells. This article aims to provide an overview of the causes and treatment options for Premature Ovarian Insufficiency, with a particular focus on stem cell therapy as suggested by previous studies. Corresponding Author: Hossein Kalarestaghy, Department of Anatomical Sciences, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

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