The Effect of Physical Activity on Stress and Inflammation in Mice with Rheumatoid Arthritis

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Payamipour Sheida; Peeri Maghsoud; Azarbaijani Mohammad Ali; Fattahi Masrour Forouzan

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Journal Paper

Paper Information

Journal: Journal of Ardabil University of Medical Sciences Year:2024 | Volume: | Issue: Page(s): 92-106

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Information Journal Paper

Title

The Effect of Physical Activity on Stress and Inflammation in Mice with Rheumatoid Arthritis

Author(s)

Payamipour Sheida | Peeri Maghsoud | Azarbaijani Mohammad Ali | Fattahi Masrour Forouzan | Issue Writer Certificate

Keywords

ExerciseQ4

StressQ4

Rheumatoid ArthritisQ4

InflammationQ4

Abstract

2Background: Rheumatoid Arthritis is an autoimmune disease that gradually destroys the synovial joints and leads to chronic Inflammation. This autoimmune disorder is associated with an increase in Stress-related symptoms, including anxiety and depression, and a decrease in social behaviors, which severely reduces the patient's quality of life. Previous studies show that higher physical activity during adolescence may lead to a decrease in neurobehavioral disorders in adulthood. This study was conducted with the aim of evaluating the increase of physical activity from early adolescence on Stress-related behaviors and Inflammation in mice with Rheumatoid Arthritis. Methods: Male mice were randomly exposed to a running wheel from early adolescence to adulthood, and then Rheumatoid Arthritis was induced. Stress-related behaviors, including anxiety, depression and social behavior were investigated in animals. The level of interleukin 17 (IL-17) and interferon gamma (IFN-γ) were also measured as important inflammatory markers in the serum. Results: The results showed that physical activity from early adolescence significantly resulted in decreased Stress in mice with Rheumatoid Arthritis. In addition, the running wheel led to a decrease in the levels of (IL-17) and (IFN-γ) in Rheumatoid Arthritis-induced mice as two important indicators of Inflammation. Conclusion: This study shows that increased physical activity during adolescence to adulthood may make mice resistant to increased Stress and Inflammation caused by rheumatic arthritis.

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