The Effect of Exercise Training on Inflammatory Markers in Patients with Multiple Sclerosis: A Systematic Review and Meta-Analysis

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Khalafi Mousa; Mohammadi Dinani Sanaz; Sadat Hosseini Marzieh; Sharifmoradi Keyvan

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Isfahan Medical School Year:2023 | Volume:41 | Issue:749 Page(s): 1157-1169

Download Full-Text

Persian Verion

View:

Download:

Cites:

Information Journal Paper

Title

The Effect of Exercise Training on Inflammatory Markers in Patients with Multiple Sclerosis: A Systematic Review and Meta-Analysis

Author(s)

Khalafi Mousa | Mohammadi Dinani Sanaz | Sadat Hosseini Marzieh | Sharifmoradi Keyvan | Issue Writer Certificate

Keywords

ExerciseQ4

CytokinesQ4

InflammationQ4

C-Reactive ProteinQ4

Interleukin-6Q4

Interleukin-10Q4

Tumor Necrosis Factor-alphaQ4

Multiple SclerosisQ4

Abstract

Background: Multiple Sclerosis (MS) is a progressive inflammatory disease in which inflammatory markers play an effective role in the development of this disease. In contrast, Exercise training may lead to improved chronic Inflammation. However, the effect of Exercise training on inflammatory markers is not clearly understood. Therefore, the purpose of this meta-analysis is to investigate the effect of Exercise training on IL-6, TNF-α, and IL-10 as well as CRP in patients with MS.Methods: A comprehensive search was conducted in the three principal databases of PubMed, Web of Science, and Scopus for English and Persian articles published until December 22, 2022. To determine the effect sizes of the effect of Exercise training on inflammatory markers IL-6, IL-10, TNF-α, and CRP, standardized mean difference (SMD) and 95% confidence intervals (CIs) were calculated.Findings: Sixteen studies involving 687 patients with MS were included in the meta-analysis. Exercise training resulted in a significant decrease in levels of IL-6 [P = 0.002, (CI: -0.14 to 0.65: -0.40)] and CRP [P = 0.02 -0.04 to 0.70 CI: -0.37], but did not lead a significant effect on the levels of TNF-α [P = 0.20, (0.14 to 0.68 CI: -) -0.27] and IL -10 [P = 0.94, (0.43 to 0.40 CI: -0.15)].Conclusion: Exercise training may lead to improvement of chronic Inflammation status by reducing IL-6 and CRP in patients with MS. Therefore, prescribing regular Exercise may be a suitable approach for disease management in patients with MS.

Cites

No record.

References