The relationship between ACE I/D gene polymorphism rs4646994 and incidence and severity of sport injuries in Iranian male elite weightlifters

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Batavani Mohammad Reza; Zalaki Badil Forogh; Zolaktaf Vahid

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Journal Paper

Paper Information

Journal: Journal of Basic Research in Medical Sciences Year:2023 | Volume:10 | Issue:2 Page(s): 62-73

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Title

The relationship between ACE I/D gene polymorphism rs4646994 and incidence and severity of sport injuries in Iranian male elite weightlifters

Author(s)

Batavani Mohammad Reza | Zalaki Badil Forogh | Zolaktaf Vahid | Issue Writer Certificate

Keywords

Sports GenomicsQ4

Sport InjuriesQ4

WeightliftersQ4

EliteQ4

Abstract

Introduction: Despite careful control of environmental factors, there is a wide variety of interpersonal muscle-induced muscle damage. Genetic changes can also be important in determining susceptibility to injury. Weightlifting is one of the most successful Iranian sports teams in Olympics; so, the aim of this study was the investigation of the relationship between ACE I/D gene polymorphism rs4646994 and incidence and severity of Sport Injuries in Iranian male Elite Weightlifters. Materials and Methods: The study was cross-sectional research that conducted in 2022. The statistical population consisted of male Elite Weightlifters from Isfahan consisting of 31 athletes who all were investigated as sample. A questionnaire was used to collect the injuries data. Saliva samples were taken from all subjects and DNA was extracted and genotyped by using real-time polymerase chain reaction (real time-PCR). Chi-square and regression tests were used to analyze the data. Significance level was also considered at P < 0.05. Results: There was a significant difference in the incidence of injuries in different genotypes. ID genotype (59.4%) had the highest incidence of injury in compare with DD (23.2%) and II (17.4%) genotypes (χ2 = 21.47, P = 0.001). Also, there was a significant difference in the severity of injuries in different genotypes (χ2 =15.59, P = 0.049); but there was no relationship between genotype and incidence and the severity of sports injuries in selected Iranian Elite male Weightlifters (P = 0.715). Conclusion: The results showed differences in the incidence and severity of Sport Injuries in different genotypes, hence it would be important in the prediction injury risk in Weightlifters.

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