Effect of Creatine Supplementation on Post-Exercise Recovery and Muscle injuries Factors in Healthy Subjects: A Systematic Review and Meta-analysis of Clinical Trial Studies

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Kazemi nasab F.; Mehvari Habib Abadi M.; Rouhi A.; Hassan pour N.

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Journal Paper

Paper Information

Journal: Iranian Journal of Endocrinology & Metabolism Year:2023 | Volume:25 | Issue:4 Page(s): 364-383

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Information Journal Paper

Title

Effect of Creatine Supplementation on Post-Exercise Recovery and Muscle injuries Factors in Healthy Subjects: A Systematic Review and Meta-analysis of Clinical Trial Studies

Author(s)

Kazemi nasab F. | Mehvari Habib Abadi M. | Rouhi A. | Hassan pour N. | Issue Writer Certificate

Keywords

Exercise trainingQ4

Creatine kinaseQ4

Lactate dehydrogenaseQ4

CreatineQ4

Muscle sorenessQ4

Abstract

Introduction: Several studies have investigated the effect of Creatine supplementation on indirect markers of muscular damage and sports performance of athletes. However, pooled data from several studies suggest that the benefits of Creatine on recovery of athletes are limited. The aim of this study was to investigate the effect of Creatine supplementation on post-exercise recovery and muscle injury factors in healthy subjects. Materials and Methods: A systematic search of articles published in English and Persian databases until November 2023 was conducted to investigate the effect of Creatine supplementation on muscle injury markers Creatine kinase/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">Creatine kinase (CK) and Lactate dehydrogenase (LDH) and Muscle soreness in healthy subjects. Weighted mean difference (WMD) and standardized mean difference (SMD) and 95% confidence interval were calculated using random effect model. Results: A total of 20 studies including 458 subjects were included in the present meta-analysis. The results showed that Creatine did not cause a significant change in Muscle soreness in any of 24, 48, 72, and 96 hours after exercise compared to the control group. Also, Creatine did not cause a significant change in CK in any time spectrum compared to the control group. In addition, Creatine did not cause a significant change in LDH in different time ranges after exercise compared to the control group in athletes and non-athletes. Conclusion: The results of the present study show that Creatine supplementation is not effective in reducing Muscle soreness and muscle injury factors after exercise.

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