Fighting Against Aging-Related Dysfunction Under Variable Stress: Possible Antioxidant and Neuroprotective Roles of Metformin via Increased Superoxide Dismutase and Brain-Derived Neurotrophic Factor

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Pak Hashemi Mohammad; Hassanipour Mahsa; Kaeedi Ayat; Saeed Askari Pooya; Fatemi Iman; Taghipour Zahra; Mohammadi Mohadeseh; Allahtavakoli Mohammad

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Archives of Neuroscience Year:2023 | Volume:10 | Issue:4 Page(s): 1-11

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Fighting Against Aging-Related Dysfunction Under Variable Stress: Possible Antioxidant and Neuroprotective Roles of Metformin via Increased Superoxide Dismutase and Brain-Derived Neurotrophic Factor

Author(s)

Keywords

AgingQ4

Behavioral FunctionQ4

BDNFQ4

MetforminQ4

Oxidative StressQ4

StressQ4

Abstract

Background: Chronic Stress causes a deleterious impact on older adults and accelerates the Aging process through different mechanisms, such as increased Stress/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">Oxidative Stress. Metformin, a drug with pleiotropic effects, exhibited neuroprotective and antioxidant properties. Objectives: Our study aimed to investigate the Metformin effects on Aging under Stress conditions. Methods: Old male rats (18 months) were divided into 6 experimental groups (N = 8): 1 = control; 2 and 3 = Metformin (1 or 10 mg/kg, orally, 40 days); 4 = Stress (40 days); 5 and 6 = Stress + Metformin (1 or 10 mg/kg, orally, 40 days). Chronic variable Stress was induced with 7 types of Stressors for 40 days. NeuroBehavioral Functions were evaluated using the Morris water maze, Y-maze, elevated plus maze, open field, forced swimming test, rotarod, and exhausting swimming test. In addition, BDNF level and SOD activity were measured. Results: Stress induction increased memory deficits, anxiety, depression, and muscle fatigue in old rats. Metformin (10 mg/kg) enhanced memory performance and muscle strength and diminished anxiety and depression in Stressed animals (P < 0.05). Treatment with Metformin increased the BDNF brain level and SOD activity (P < 0.05). Conclusions: Metformin restored neurobehavioral disruptive changes induced by chronic Stress in old rats. The underlying mechanisms could be related to the prevention of Stress/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">Oxidative Stress and neuronal damage and elevation of BDNF levels in the brain.

Cites

No record.

References