Evaluating the oxidative stress markers and nitric oxide levels of liver in the experimental model of diabetes mellitus

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Marefati Narges; Shabani Navidiyan Aniseh; Bahari Zahra; Mohammadi Mohammad Taghi

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Journal: Pathobiology Research Year:2023 | Volume:26 | Issue:2 Page(s): 61-67

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Title

Evaluating the oxidative stress markers and nitric oxide levels of liver in the experimental model of diabetes mellitus

Author(s)

Marefati Narges | Shabani Navidiyan Aniseh | Bahari Zahra | Mohammadi Mohammad Taghi | Issue Writer Certificate

Keywords

Diabetes mellitusQ4

Liver dysfunctionQ4

Antioxidant capacityQ4

Oxidative stressQ4

Abstract

Introduction: Occurrence of Oxidative stress and alterations of its related variables during Diabetes mellitus is one of the main reasons of tissue damage and dysfunction. Therefore, we assessed the Oxidative stress markers and nitric oxide levels of liver in the streptozotocin-induced Diabetes mellitus in rats. Methods: To perform the study, male Wistar rats were randomly divided into two groups (n=6): normal and diabetic groups. A single intravenous injection of streptozotocin (45 mg/kg) was used for inducing diabetes. At termination of the study, the Oxidative stress markers were determined in the livers, including the contents of malondialdehyde (MDA) and NOx (nitrite/nitrate) as well as the activity of superoxide dismutase (SOD). Results: Induction of diabetes increased blood glucose of the diabetic rats above 450 mg/dl. This value in diabetic rats did not change during the study. Diabetes increased the MDA levels in the livers of diabetic rats compared to normal group. The SOD activity of livers decreased in diabetic animals compared to normal rats. Also, NOx content of liver decreased in the livers of diabetic animals compared to normal group. Conclusion: It is concluded that chronic hyperglycemia in diabetic states overproduces ROS and causes Oxidative stress in liver by weakening the Antioxidant capacity. Diabetes also alters the NO biosynthesis and bioavailability of liver, which can lead to Liver dysfunction.

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