Investigating the Neurotoxicity Caused by Tricyclazole and Thiophanate Methyl in Wistar Rats

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Harsini Z.; Hosseini S.M.; Pourabdolhossein F.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Journal of Babol University of Medical Sciences Year:2023 | Volume:25 | Issue:1 Page(s): 108-115

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Information Journal Paper

Title

Investigating the Neurotoxicity Caused by Tricyclazole and Thiophanate Methyl in Wistar Rats

Author(s)

Harsini Z. | Hosseini S.M. | Pourabdolhossein F. | Issue Writer Certificate

Keywords

Tricyclazole

Thiophanate Methyl

Hippocampus

Neurons

Histopathology.

Abstract

Background and Objective: Along with the steady growth of the population, the widespread use of systemic fungicides, which leads to increased productivity and higher yield of food products, has been given a lot of attention. Therefore, considering the cytotoxic effects of systemic fungicides Tricyclazole and Thiophanate Methyl, the present study was conducted with the aim of investigating the neurotoxicity caused by the use of fungicides Tricyclazole (TCZ) and Thiophanate Methyl (TM) in Wistar rats.
Methods: In this experimental study, 32 male Wistar rats were randomly divided into 4 groups of 8 including: control group, groups receiving pesticide mixtures orally at doses of (A) TM 664 + TCZ 25, (B) TM 498 + TCZ 19 and (C) TM 332 + TCZ 13 (mg/kg body weight) and brain tissue sampling was done after 28 days. Nissl and hematoxylin-eosin staining were used for qualitative assessment of pathological lesions and quantitative counting of brain cells.
Findings: In the histopathological examinations of the groups that received toxins, it was observed that the Neurons became necrotic, and the increase of microglia cells in the Hippocampus and cerebral cortex was also observed. The results of cell counting indicated the lowest number of Neurons in group A in the cerebral cortex (171.40±4.88), CA1 (152.80±5.99), CA2,3 (127.90±8.36) and CA4 (59.20±3.86), which showed a significant decrease compared to the control group (p<0.05).
Conclusion: The results of the study showed that the mixture of Tricyclazole and Thiophanate Methyl caused damage to brain Neurons in the cerebral cortex and different areas of the Hippocampus and subsequently caused a decrease in the number of Neurons in these areas; Of course, the amount of damage was directly related to increase in the dose.

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