Evaluation of the effect of Rosmarinic acid on depression by forced swimming and tail suspension tests in mice model compared to citalopram

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Amanpour Hassan; Saberi Mehdi; Salem Fatemeh; Mashhadi Akbar Boojar Mahdi

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Journal Paper

Paper Information

Journal: Journal of Medical Council of Iran Year:2023 | Volume:41 | Issue:1 Page(s): 41-52

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Information Journal Paper

Title

Evaluation of the effect of Rosmarinic acid on depression by forced swimming and tail suspension tests in mice model compared to citalopram

Author(s)

Amanpour Hassan | Saberi Mehdi | Salem Fatemeh | Mashhadi Akbar Boojar Mahdi | Issue Writer Certificate

Keywords

Rosmarinic acidQ4

MiceQ4

DepressionQ4

CitalopramQ4

Forced swimming testQ4

Tail suspension test.Q4

Abstract

Background: Common anti-depressant drugs have various and sometimes serious side effects that can cause intolerance and arbitrary discontinuation of the drug by the patient. In this research, the anti-depressant effects of Rosmarinic acid were investigated in Mice and in groups of seven members using the Forced swimming test (FST) and Tail suspension test.(TST). Methods: For this purpose, intraperitoneal injection of Rosmarinic acid with doses of 50, 20, 10, and 5 mg/kg in 5 groups of rats, as well as gavage of Citalopram suspension with doses of 15 mg/kg in 2 groups and injection of normal saline in the control group for 7 days and then the FST and TST tests were performed. The mean ± standard error of the data obtained from each group was analyzed separately by one-way ANOVA test and P<0.05 was considered significant in each test. Results: Rosmarinic acid in doses of 5, 10, and 20 mg/kg in both FST and TST tests had significant antidepressant effects compared to the group receiving normal saline (P<0.05) and also in the group receiving Citalopram 15 mg/kg along with 50 mg/kg. Rosmarinic acid showed a significant difference in antidepressant effects compared to the group receiving normal saline (P<0.01). The dose of 50 mg/kg of Rosmarinic acid did not have significant antidepressant effects compared to the control group. Conclusion: The findings indicate that Rosmarinic acid in low and medium doses has obvious and significant antidepressant effects compared to the normal saline control group, but it does not have an obvious superiority compared to Citalopram. An antidepressant effect was not observed in the high dose of Rosmarinic acid, which could be due to the predominance of its sedative effects. Therefore, it can be concluded that the antidepressant effects of this agent are not dose-dependent and follows a U-shaped dose-response curve.

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