ASSOCIATION OF VASPIN RS2236242 GENE POLYMORPHISM WITH NON-ALCOHOLIC FATTY LIVER DISEASE

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Ehtesham Roghayeh; Nezhadali Masoumeh; Hedayati Mehdi

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Journal Paper

Paper Information

Journal: Studies in Medical Sciences Year:2024 | Volume:35 | Issue:8 Page(s): 652-661

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Information Journal Paper

Title

ASSOCIATION OF VASPIN RS2236242 GENE POLYMORPHISM WITH NON-ALCOHOLIC FATTY LIVER DISEASE

Author(s)

Ehtesham Roghayeh | Nezhadali Masoumeh | Hedayati Mehdi | Issue Writer Certificate

Keywords

vaspin

Non-alcoholic fatty liver

Insulin resistance index

Abstract

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease and a major public health problem worldwide. NAFLD has been steadily increasing in prevalence and is associated with serious complications such as cirrhosis and hepatocellular carcinoma, It is also linked to insulin resistance syndrome and cardiovascular diseases. In this study, the association of vaspin rs2236242 gene polymorphism with NAFLD is investigated.
Materials & Methods: The case-control study (random sampling) was conducted on 150 participants, includes 75 participants with Non-alcoholic fatty liver diseases as cases and 75 participants as normal group. Participants with a history of alcohol consumption, metabolic disorders or other liver diseases were excluded from the study. The serum vaspin and insulin were measured by ELISA kit and other variables by standard method. Determining the genotypes of rs2236242 was done using the tetra arms polymerase chain reaction. Statistical analysis was performed using SPSS software version 20.
Results: There was no significant difference in vaspin levels in the patients with NAFLD compared with healthy individuals (p ≥0.05). The levels of any of the variables in healthy individuals and patients for GG, AG, and AA genotypes were not significantly different. There was no a significant relationship between rs2236242polymorphism and insulin resistance. No association was found between this polymorphism and NAFLD (p ≥0.05).
Conclusion: The findings showed that there is no relationship between rs2236242 polymorphism with vaspin levels, insulin resistance and Non-alcoholic fatty liver disease. However, limitations such as the limited sample size and the use of ultrasound affect the generalizability of the findings.

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