The Effect of Interval Training on the Expression of Tumor Suppressor Gene, Systemic Inflammation, and Tumor Volume in Breast Cancer– Bearing BALB/c Mice

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Sadeghipoor Vojdani F.; AGHA ALINEJAD H.; MOLANOURI SHAMSI M.; SOUDI S.; Khanchi S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Breast Diseases Year:2019 | Volume:12 | Issue:3 (46) Page(s): 17-25

Download Full-Text

Persian Verion

View:

662

Download:

Cites:

Information Journal Paper

Title

The Effect of Interval Training on the Expression of Tumor Suppressor Gene, Systemic Inflammation, and Tumor Volume in Breast Cancer– Bearing BALB/c Mice

Author(s)

Keywords

E-CadherinQ1

High-intensity Interval TrainingQ1

Breast CancerQ2

MetastasisQ3

Abstract

Introduction: E-Cadherin is expressed in most normal epithelial tissues. Loss of E-Cadherin can cause dedifferentiation and invasiveness in human carcinomas, leading E-Cadherin to be classified as a tumor suppressor. Therefore, the aim of this study was to investigate the effect of interval training on the expression of tumor suppressor gene E-Cadherin in Breast Cancer-bearing BALB/c mice. Methods: Twenty female BALB/c mice were purchased from the Pasteur Institute and transferred to the Animal Laboratory of Tarbiat Modares University and randomly divided into four groups of training-cancer-rest, training-cancer-training, rest-cancer-rest, and rest-cancer-training. Cancer was induced by subcutaneous injection of 4T1 cell line. The mice performed an average-intensity interval training for 10 weeks, 5 days per week. Forty-eight hours after the last exercise session, the mice were sacrificed to measure the research variables. Gene expression was investigated using real-time PCR. The Kruskal-Wallis test was used to determine the statistical differences between groups. Results: There was a significant difference in the E-Cadherin gene expression between the training-cancer-training and rest-cancer-rest groups (p = 0. 03). This difference was also observed between the training-cancertraining and training-cancer-rest groups (p = 0. 04). Conclusion: Interval exercise training may influence the expression of major tumor suppressor genes and systemic inflammation involved in the development of Metastasis and even reverse this process.

Cites

No record.

References

Cite

APA: Copy

Sadeghipoor Vojdani, F., AGHA ALINEJAD, H., MOLANOURI SHAMSI, M., SOUDI, S., & Khanchi, S.. (2019). The Effect of Interval Training on the Expression of Tumor Suppressor Gene, Systemic Inflammation, and Tumor Volume in Breast Cancer– Bearing BALB/c Mice. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, 12(3 (46) ), 17-25. SID. https://sid.ir/paper/144569/en

Vancouver: Copy

Sadeghipoor Vojdani F., AGHA ALINEJAD H., MOLANOURI SHAMSI M., SOUDI S., Khanchi S.. The Effect of Interval Training on the Expression of Tumor Suppressor Gene, Systemic Inflammation, and Tumor Volume in Breast Cancer– Bearing BALB/c Mice. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE[Internet]. 2019;12(3 (46) ):17-25. Available from: https://sid.ir/paper/144569/en

IEEE: Copy

F. Sadeghipoor Vojdani, H. AGHA ALINEJAD, M. MOLANOURI SHAMSI, S. SOUDI, and S. Khanchi, “The Effect of Interval Training on the Expression of Tumor Suppressor Gene, Systemic Inflammation, and Tumor Volume in Breast Cancer– Bearing BALB/c Mice,” IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, vol. 12, no. 3 (46) , pp. 17–25, 2019, [Online]. Available: https://sid.ir/paper/144569/en

Related Journal Papers