Effectiveness of Ceftazidime-Avibactam versus Colistin against Carbapenem-Resistant Enterobacteriaceae- A Retrospective Study

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Gopikrishnan Nilaa; Nair Krishna S.; Mathew Elsa; Narasimhan Denesh; Alagesan Murali

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Infection Epidemiology and Microbiology Year:2024 | Volume:10 | Issue:2 Page(s): 111-121

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Effectiveness of Ceftazidime-Avibactam versus Colistin against Carbapenem-Resistant Enterobacteriaceae- A Retrospective Study

Author(s)

Keywords

Carbapenem-resistant Enterobacteriaceae

Ceftazidime

Colistin

Drug resistance

Microbial

Outcomes

Abstract

Background: This study compared the efficacy of Ceftazidime-avibactam (CAZ-AVI) with Colistin for treating Carbapenem-resistant Enterobacteriaceae (CRE) infections. Materials & Methods: This retrospective study included 120 patients with a confirmed CRE infection and information on causative bacteria and their susceptibility pattern. Patients were divided into two groups: those receiving CAZ-AVI and/or aztreonam (n=53) and those receiving Colistin (n=67) for at least seven days. The Colistin group was further subdivided into those who switched to CAZ-AVI due to poor Outcomes. Patient data, including demographics, clinical history, microbiological data, Charlson comorbidity index, and Outcomes, were collected and analyzed. Mann-Whitney U, Chi-square, and Fisher’s exact tests were used to compare the groups. P< .05 was considered statistically significant. Findings: The findings revealed comparable clinical characteristics, there were no major differences in mean duration of hospitalization, intensive care unit (ICU) admission, and Charlson scores between the two groups. The CAZ-AVI group required a significantly longer duration of antibiotic treatment (p= .018) and more source control measures (p= .009). Klebsiella pneumoniae was the predominant causative pathogen in both groups, with NDM and OXA48 carbapenem resistance genes being the most common. Toxicity (p= .001) and mortality (p= .049) were significantly higher in the Colistin group. Higher improvement was observed among the CAZ-AVI group and higher mortality among the Colistin group (p= .049). Conclusion: CAZ-AVI could serve as an alternative to Colistin for treating CRE infections. Further research is necessary to confirm these findings and provide evidence-based guidelines for managing CRE infections in India.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans