TIME-DEPENDENT CHANGES IN RESPONSIVENESS OF THORACIC AORTA OF DIABETIC RATS TO QUERCETIN

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ROUGHANI M.; BALUCHNEJADMOJARAD TOURANDOKHT

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Medicinal Plants Year:2006 | Volume:5 | Issue:Supplement Page(s): 17-22

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Title

TIME-DEPENDENT CHANGES IN RESPONSIVENESS OF THORACIC AORTA OF DIABETIC RATS TO QUERCETIN

Author(s)

ROUGHANI M. | BALUCHNEJADMOJARAD TOURANDOKHT | | | Issue Writer Certificate

Keywords

QUERCETINQ4

THORACIC AORTAQ2

DIABETES MELLITUSQ3

RATQ3

Abstract

Background and Objective: Cardiovascular disorders are amongst the most prevalent complications of DIABETES MELLITUS in long term. Since vascular responsiveness to vasoactive agents changes in diabetes with time, this experimental study was conducted to evaluate time-dependent changes in the responsiveness of THORACIC AORTA of diabetic RATs to the flavonoid QUERCETIN. Methods: For this purpose, male wistar RATs were divided into control and experimental groups. For induction of diabetes, streptozotocin (i.p.) was used. The body weight and serum glucose parameters were determined before and at 2nd, 4th, and 8th weeks after the experiment. Contractile responsiveness to KCl and noreadrenalin (NA) and QUERCETINinduced vasorelaxation were measured at 4th and 8th weeks. Results: The results showed that after 4 and 8 weeks, QUERCETIN (0.1 μM-1 mM) induced a dose-dependent vasorelaxation in aortic rings precontracted with KCl and/or NA from both control and diabetic groups. Furthermore, this vasorelaxation was significantly attenuated in diabetic group eight weeks after the study in comparison with data at fourth week. Conclusion: It can be concluded that the vasorelaxant effect of this flavonoid is attenuated in DIABETES MELLITUS with time.

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APA: Copy

ROUGHANI, M., & BALUCHNEJADMOJARAD, TOURANDOKHT. (2006). TIME-DEPENDENT CHANGES IN RESPONSIVENESS OF THORACIC AORTA OF DIABETIC RATS TO QUERCETIN. JOURNAL OF MEDICINAL PLANTS, 5(Supplement), 17-22. SID. https://sid.ir/paper/15202/en

Vancouver: Copy

ROUGHANI M., BALUCHNEJADMOJARAD TOURANDOKHT. TIME-DEPENDENT CHANGES IN RESPONSIVENESS OF THORACIC AORTA OF DIABETIC RATS TO QUERCETIN. JOURNAL OF MEDICINAL PLANTS[Internet]. 2006;5(Supplement):17-22. Available from: https://sid.ir/paper/15202/en

IEEE: Copy

M. ROUGHANI, and TOURANDOKHT BALUCHNEJADMOJARAD, “TIME-DEPENDENT CHANGES IN RESPONSIVENESS OF THORACIC AORTA OF DIABETIC RATS TO QUERCETIN,” JOURNAL OF MEDICINAL PLANTS, vol. 5, no. Supplement, pp. 17–22, 2006, [Online]. Available: https://sid.ir/paper/15202/en

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