Additive Effects of Clonidine Used in Propofol Sedation in Colonoscopy

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Mohamed Mohamed Rabab; Elsayed Elgahrib Abdalla Ashraf; M. Eissa Mohsen; Khalil Abdelrahman Reda; Galal Flefel Mohamed; Abdelbadie Asmaa; Mohammad Ezzat Hamed Darwish Jehan

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Journal Paper

Paper Information

Journal: Anesthesiology and Pain Medicine Year:2025 | Volume:15 | Issue:1 Page(s): 1-8

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Title

Additive Effects of Clonidine Used in Propofol Sedation in Colonoscopy

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Keywords

Colonoscopy

Sedation

Propofol

Clonidine

Patient Satisfaction

Abstract

Background: Propofol is commonly used for Sedation during Colonoscopy but often requires high doses. Objectives: This study aimed to compare the outcomes of Propofol alone versus Propofol combined with Clonidine for Colonoscopy Sedation. Methods: In this randomized, double-blind controlled trial, 60 adult patients scheduled for elective Colonoscopy were enrolled. Patients were divided into two groups: Group 1 (G1) received Propofol alone, while group 2 (G2) received Propofol plus 2 μg/kg Clonidine intravenously over 10 minutes. Propofol infusion was initiated at 25 - 75 μg/kg/min IV for the first 10 - 15 minutes, then titrated to 25 - 50 μg/kg/min based on clinical response. Results: Sedation onset was significantly faster in G2 than in G1 (P = 0.001). The total Propofol requirement was 22% lower in G2 (P = 0.001). Heart rate (HR) and mean arterial pressure (MAP) were significantly lower in G2 at induction and at the end of the procedure (P < 0.05). Patient Satisfaction scores were higher in G2 (P = 0.042). The observer's assessment of alertness/Sedation (OAA/S) score after induction was lower in G2 (P = 0.015), indicating deeper Sedation. However, Aldrete scores in the post-anesthesia care unit (PACU) were lower in G2 (P = 0.001), suggesting a slower recovery. Conclusions: The addition of Clonidine to Propofol for Colonoscopy Sedation led to faster Sedation onset, reduced Propofol requirements, improved Patient Satisfaction, and deeper Sedation, but with potentially prolonged recovery times.

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