THE EFFECT OF HYDROALCOHOLIC EXTRACT OFECHINOPS CEPHALOTS L. ON EXPRESSION OF INFLAMMATORY FACTORS IN CHONDROCYTES AND THP-1 CELLS AS A MODEL OF MONOCYTE/MACROPHAGE AND HUMAN CARTILAGE CELLS IN OSTEOARTHRITIS

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TAHERIAN M.; MAGHSOUDI H.; TAHERIAN R.; RASTEGAR H.

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Journal Paper

Paper Information

Journal: Journal of Medicinal Plants Year:2018 | Volume:17 | Issue:66 Page(s): 145-155

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Title

THE EFFECT OF HYDROALCOHOLIC EXTRACT OFECHINOPS CEPHALOTS L. ON EXPRESSION OF INFLAMMATORY FACTORS IN CHONDROCYTES AND THP-1 CELLS AS A MODEL OF MONOCYTE/MACROPHAGE AND HUMAN CARTILAGE CELLS IN OSTEOARTHRITIS

Author(s)

TAHERIAN M. | MAGHSOUDI H. | TAHERIAN R. | RASTEGAR H. | Issue Writer Certificate

Keywords

ECHINOPS CEPHALOTESQ1

CHONDROCYTEQ1

CYTOKINEQ1

MONOCYTE/MACROPHAGEQ1

OSTEOARTHRITISQ1

Abstract

Background: OSTEOARTHRITIS (OA) is one of the main causes of physical disability worldwide. Considering the complications of common treatments of OA, including non-steroidal antiinflammatory drug (NSAIDs) and corticosteroids, establishment of new treatments is crucial.Objective: This study aimed to explore the effect of ECHINOPS CEPHALOTES extract on the main inflammatory biomarkers in OA.Methods: Hydroalcoholic extract of ECHINOPS CEPHALOTES, Ibuprofen and betamethasone were prepared to investigate their effects on inflammatory biomarkers. Human MONOCYTE/MACROPHAGE (THP-1) cells and CHONDROCYTEs cells were used as a model of MONOCYTE/MACROPHAGE and human cartilage cells in OSTEOARTHRITIS. Lipopolysaccharide (LPS) was used to induce production of inflammatory CYTOKINEs in both cells. After RNA extraction and production of cDNA, RT_PCR & PCR were done. Then Real Time-PCR was used to investigate the amount of expression of proinflammatory genes.Results: ECHINOPS CEPHALOTES extract reduced mRNA expression level of proinflammatory CYTOKINEs in the cells induced by LPS. Moreover, production of PGE2 and NO in in the LPSinduced THP-1 cells was reduced by this extract. Ibuprofen and betamethasone were more effective in reducing above inflammatory agents than the extract.Conclusion: ECHINOPS CEPHALOTES extract can be used as a supplementary treatment option in OSTEOARTHRITIS to reduce NSAIDs and corticosteroids dose in treatment of this disease.

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References

ETHNOBOTANICAL INVESTIGATION OF TRADITIONAL MEDICINAL PLANTS COMMERCIALIZED IN THE MARKETS OF MASHHAD, IRAN

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APA: Copy

TAHERIAN, M., MAGHSOUDI, H., TAHERIAN, R., & RASTEGAR, H.. (2018). THE EFFECT OF HYDROALCOHOLIC EXTRACT OFECHINOPS CEPHALOTS L. ON EXPRESSION OF INFLAMMATORY FACTORS IN CHONDROCYTES AND THP-1 CELLS AS A MODEL OF MONOCYTE/MACROPHAGE AND HUMAN CARTILAGE CELLS IN OSTEOARTHRITIS. JOURNAL OF MEDICINAL PLANTS, 17(66 ), 145-155. SID. https://sid.ir/paper/15218/en

Vancouver: Copy

TAHERIAN M., MAGHSOUDI H., TAHERIAN R., RASTEGAR H.. THE EFFECT OF HYDROALCOHOLIC EXTRACT OFECHINOPS CEPHALOTS L. ON EXPRESSION OF INFLAMMATORY FACTORS IN CHONDROCYTES AND THP-1 CELLS AS A MODEL OF MONOCYTE/MACROPHAGE AND HUMAN CARTILAGE CELLS IN OSTEOARTHRITIS. JOURNAL OF MEDICINAL PLANTS[Internet]. 2018;17(66 ):145-155. Available from: https://sid.ir/paper/15218/en

IEEE: Copy

M. TAHERIAN, H. MAGHSOUDI, R. TAHERIAN, and H. RASTEGAR, “THE EFFECT OF HYDROALCOHOLIC EXTRACT OFECHINOPS CEPHALOTS L. ON EXPRESSION OF INFLAMMATORY FACTORS IN CHONDROCYTES AND THP-1 CELLS AS A MODEL OF MONOCYTE/MACROPHAGE AND HUMAN CARTILAGE CELLS IN OSTEOARTHRITIS,” JOURNAL OF MEDICINAL PLANTS, vol. 17, no. 66 , pp. 145–155, 2018, [Online]. Available: https://sid.ir/paper/15218/en

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