STUDY OF ACUTE AND CHRONIC ANTIHYPERGLYCEMIC ACTIVITY OF METHANOLIC EXTRACT OF SALVIA MIRZAYANII RECH. & ESFAND. IN RATS

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MEHRABANI MITRA; HEYDARI MAHMOUD REZA; MEHRABANI MEHRNAZ

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Journal: Journal of Medicinal Plants Year:2010 | Volume:9 | Issue:36 Page(s): 106-116

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Title

STUDY OF ACUTE AND CHRONIC ANTIHYPERGLYCEMIC ACTIVITY OF METHANOLIC EXTRACT OF SALVIA MIRZAYANII RECH. & ESFAND. IN RATS

Author(s)

MEHRABANI MITRA | HEYDARI MAHMOUD REZA | MEHRABANI MEHRNAZ | Issue Writer Certificate

Keywords

SALVIA MIRZAYANIIQ3

DIABETESQ3

STREPTOZOCINQ3

RATQ3

METHANOLIC EXTRACTQ3

Abstract

Background: In folk medicine, there are many uses of useful effects of some medicinal plants for treatment of disease. In traditional medicine of Kerman province, SALVIA MIRZAYANII Rech. & Esfand. (Lamiaceae) or Mor-e-Porzo applies for treatment of DIABETES mellitus. Literature reviews showed another species of Salvia had antidiabetic effects. Objective: In this study anti hyperglycemic activities of this plant were evaluated.Methods: Eleven group (n=7) of male white RATs (six normal and five diabetic) used. DIABETES induced by IP injection of STREPTOZOCIN (STZ) (64 mg/kg). DIABETES was allowed to develop in these STZ treated RAT over of 24h, and animals treated by 50, 100, 200, 400 mg/kg of the dried metanolic extract by IP injection for 24 hours and 400 mg/kg for 12 days. Finally, surgery carried out on these animals and liver and pancreas studied histopathologically. For statistic, used ANOVA with Turkeys' post hoc.Results: The maximal reduction in the blood glucose concentration of the fasted RATs occurred at extract 400 mg/kg dose of extract. This dose (400 mg/kg) significantly reduced the blood glucose concentrations (p<0.01). On the other hand, histopathological studies showed this extract could repair and increase blood supply of pancreatic cells of these diabetic animals.Conclusion: METHANOLIC EXTRACT of S. mirzayanii could reduce blood glucose of these diabetic animals and its considerable effects on damaged pancreatic tissue, persuade the complemented studies and investigation on this plant.

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APA: Copy

MEHRABANI, MITRA, HEYDARI, MAHMOUD REZA, & MEHRABANI, MEHRNAZ. (2010). STUDY OF ACUTE AND CHRONIC ANTIHYPERGLYCEMIC ACTIVITY OF METHANOLIC EXTRACT OF SALVIA MIRZAYANII RECH. & ESFAND. IN RATS. JOURNAL OF MEDICINAL PLANTS, 9(36), 106-116. SID. https://sid.ir/paper/15340/en

Vancouver: Copy

MEHRABANI MITRA, HEYDARI MAHMOUD REZA, MEHRABANI MEHRNAZ. STUDY OF ACUTE AND CHRONIC ANTIHYPERGLYCEMIC ACTIVITY OF METHANOLIC EXTRACT OF SALVIA MIRZAYANII RECH. & ESFAND. IN RATS. JOURNAL OF MEDICINAL PLANTS[Internet]. 2010;9(36):106-116. Available from: https://sid.ir/paper/15340/en

IEEE: Copy

MITRA MEHRABANI, MAHMOUD REZA HEYDARI, and MEHRNAZ MEHRABANI, “STUDY OF ACUTE AND CHRONIC ANTIHYPERGLYCEMIC ACTIVITY OF METHANOLIC EXTRACT OF SALVIA MIRZAYANII RECH. & ESFAND. IN RATS,” JOURNAL OF MEDICINAL PLANTS, vol. 9, no. 36, pp. 106–116, 2010, [Online]. Available: https://sid.ir/paper/15340/en

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