The Effect of aerobic training on MDA, TAC, GPX, and SOD in heart tissue of Wistar rats

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Piralaiy Elaheh; Rashwan Ismael Badrkhan; Hamidiyan Gholamreza

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Journal Paper

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Journal: SPORT AND BIOMOTOR SCIENCES Year:2024 | Volume:16 | Issue:31 Page(s): 44-55

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Title

The Effect of aerobic training on MDA, TAC, GPX, and SOD in heart tissue of Wistar rats

Author(s)

Piralaiy Elaheh | Rashwan Ismael Badrkhan | Hamidiyan Gholamreza | Issue Writer Certificate

Keywords

aerobic training

Wistar rats

MDA

TAC

GPX

SOD

Abstract

Introduction and Purpose: Cardiovascular disease is one of the main causes of death in the world. The present study aimed to determine the effect of eight weeks of aerobic exercise on the levels of MDA, TAC, GPX, and SOD in the heart tissue of healthy male Wistar rats.Materials and Methods: To implement this experimental research, 12 male Wistar rats (weight 253±21 g) aged (8 weeks) were randomly divided into 2 groups including: 1) healthy control and 2) aerobic training. The training protocol involved running on an audio-stimulated treadmill at a speed of 5-24 m/min for 10-60 minutes, 5 days a week for 8 weeks. 48 hours after the last training session, all the rats were anesthetized with a ketamine and xylazine solution. Heart tissue samples were taken from the rats. The levels of MDA, TAC, GPX, and SOD in the heart tissue samples were measured. Data were analyzed by independent t-test was used at a significance level of P<0.05.Results: The results showed that after eight weeks of intervention, SOD and GPX levels increased and TAC and MDA decreased in the training group compared to the control group, but these changes were not significant (P>0.05).Discussion and Conclusion: According to the obtained results, it is possible to say that regular aerobic training can have positive effects on the efficiency of the body's antioxidant system and neutralize the harmful effects of free radicals. Also, regular aerobic training in rats does not lead to oxidative stress.

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