ALPHA-GLUCOSIDASE INHIBITORY ACTIVITY IN HEXANE EXTRACTS OF SOME PLANTS FROM KURDISTAN PROVINCE

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POURSHARIFI M.; ZAREI M.A.

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Journal: Journal of Medicinal Plants Year:2016 | Volume:15 | Issue:58 Page(s): 120-133

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Title

ALPHA-GLUCOSIDASE INHIBITORY ACTIVITY IN HEXANE EXTRACTS OF SOME PLANTS FROM KURDISTAN PROVINCE

Author(s)

POURSHARIFI M. | ZAREI M.A. | Issue Writer Certificate

Keywords

ALPHA-GLUCOSIDASEQ2

INHIBITORQ2

PLANT EXTRACTQ3

HEXANEQ2

DIABETES MELLITUSQ1

Abstract

Background: Retard absorption of glucose by the inhibition of carbohydrate hydrolyzing enzymes is one of the therapeutic approaches to decrease the postprandial hyperglycemia.Commercial a-glucosidase INHIBITORs exhibited some serious side effects. So a great deal of attention has been paid to natural products like plants, as a reliable source for bioactive compounds.Objective: The aim of this study was to find new potent INHIBITORs for ALPHA-GLUCOSIDASE among PLANT EXTRACTs.Methods: HEXANE extracts of 60 plants species were screened for their ALPHA-GLUCOSIDASE INHIBITORy activity at 0.001, 0.01, 0.1 and 1 mg/mL concentration. ALPHA-GLUCOSIDASE activity was determined spectrophotometrically at 405 nm on a Sunrise microplate reader (Tecan- Switzerland) by measuring the quantity of p-nitrophenol released from pNPG. Acarbose, dissolved in buffer, was used as a positive control. The assay was performed in triplicate. The concentration of the extract required to inhibit 50% of ALPHA-GLUCOSIDASE activity under the assay conditions was defined as the IC50value. The results are reported as %I ± SD.Results: Descurania sophia (L.) Webb & Berth, Fumaria vailantii Loisel, Ferula Haussknechti Wolf & Rech, Haplophyllum acutifolium (DC.) G.Don, Isatis cappadociaca Desv., Eremostachys laevigata Bunge, Silene aucheriana Boiss., exhibited more than 60% ALPHA-GLUCOSIDASE INHIBITORy activity. Among them, Descurania sophia, Fumaria vailantii and Ferula haussknechti exhibited significant alpha glucosidase INHIBITORy activity with IC50 values of 0.9 mg/ml, 24.55 mg/ml and 2.71 mg/ml, respectively.Conclusion: Because of its high INHIBITORy activity and low IC50, HEXANE extract of Descurania sophia would be interesting for further detailed studies to find and characterize any new INHIBITOR for ALPHA-GLUCOSIDASE.

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References

ETHNO-MEDICINAL PLANTS USED TO CURE JAUNDICE BY TRADITIONAL HEALERS OF MASHHAD, IRAN

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APA: Copy

POURSHARIFI, M., & ZAREI, M.A.. (2016). ALPHA-GLUCOSIDASE INHIBITORY ACTIVITY IN HEXANE EXTRACTS OF SOME PLANTS FROM KURDISTAN PROVINCE. JOURNAL OF MEDICINAL PLANTS, 15(58), 120-133. SID. https://sid.ir/paper/15498/en

Vancouver: Copy

POURSHARIFI M., ZAREI M.A.. ALPHA-GLUCOSIDASE INHIBITORY ACTIVITY IN HEXANE EXTRACTS OF SOME PLANTS FROM KURDISTAN PROVINCE. JOURNAL OF MEDICINAL PLANTS[Internet]. 2016;15(58):120-133. Available from: https://sid.ir/paper/15498/en

IEEE: Copy

M. POURSHARIFI, and M.A. ZAREI, “ALPHA-GLUCOSIDASE INHIBITORY ACTIVITY IN HEXANE EXTRACTS OF SOME PLANTS FROM KURDISTAN PROVINCE,” JOURNAL OF MEDICINAL PLANTS, vol. 15, no. 58, pp. 120–133, 2016, [Online]. Available: https://sid.ir/paper/15498/en

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