ANTICONVULSANT EFFECTS OF AQUEOUS AND ETHANOLIC EXTRACTS OF HYPERICUM PERFORATUM L. IN MICE

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HOSSEINZADEH H.; KARIMI G.R.; RAKHSHANIZADEH M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Medicinal Plants Year:2004 | Volume:3 | Issue:10 Page(s): 23-30

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Title

ANTICONVULSANT EFFECTS OF AQUEOUS AND ETHANOLIC EXTRACTS OF HYPERICUM PERFORATUM L. IN MICE

Author(s)

HOSSEINZADEH H. | KARIMI G.R. | RAKHSHANIZADEH M. | Issue Writer Certificate

Keywords

HYPERICUM PERFORATUM L.Q4

ST. JOHN"S WORTQ4

ANTICONVULSANT ACTIVITYQ3

PENTYLENETETRAZOLEQ4

MAXIMAL ELECTROSHOCK SEIZUREQ3

NITRIC OXIDEQ3

HERBAL MEDICINEQ3

Abstract

We studied the ANTICONVULSANT ACTIVITY of the aqueous and ethanolic extracts of Hypericum perforatum aerial parts in mice. The PENTYLENETETRAZOLE (PTZ) and the MAXIMAL ELECTROSHOCK SEIZURE (MES) tests were used for assessing the anticonvulsive effects of this plant. In the PTZ test, the extracts (0.1-1 g/kg, i.p.) delayed the onset of tonic convulsions and protected mice against mortality. In the MES test, both extracts did not show antiseizure activity. L-NAME (1-10 mg/kg, i.p.), a NITRIC OXIDE (NO) synthase inhibitor, reduced the ANTICONVULSANT ACTIVITY of the extracts. The results of this study indicate that the extracts of H. perforatum aerial parts could contribute to the control of petit mal seizure and this effect may be partially mediated by NITRIC OXIDE pathway.

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APA: Copy

HOSSEINZADEH, H., KARIMI, G.R., & RAKHSHANIZADEH, M.. (2004). ANTICONVULSANT EFFECTS OF AQUEOUS AND ETHANOLIC EXTRACTS OF HYPERICUM PERFORATUM L. IN MICE. JOURNAL OF MEDICINAL PLANTS, 3(10), 23-30. SID. https://sid.ir/paper/15653/en

Vancouver: Copy

HOSSEINZADEH H., KARIMI G.R., RAKHSHANIZADEH M.. ANTICONVULSANT EFFECTS OF AQUEOUS AND ETHANOLIC EXTRACTS OF HYPERICUM PERFORATUM L. IN MICE. JOURNAL OF MEDICINAL PLANTS[Internet]. 2004;3(10):23-30. Available from: https://sid.ir/paper/15653/en

IEEE: Copy

H. HOSSEINZADEH, G.R. KARIMI, and M. RAKHSHANIZADEH, “ANTICONVULSANT EFFECTS OF AQUEOUS AND ETHANOLIC EXTRACTS OF HYPERICUM PERFORATUM L. IN MICE,” JOURNAL OF MEDICINAL PLANTS, vol. 3, no. 10, pp. 23–30, 2004, [Online]. Available: https://sid.ir/paper/15653/en

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