EFFICACY OF LICORICE EXTRACT IN THE TREATMENT OF MELASMA: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL

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SHAMSI MEYMANDI SIMIN; MOHAMADZADEH SHANEHSAZ SIAVASH; ANSARI DOGAHEH MEHDI; JAHANI YUNES

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Paper Information

Journal: Dermatology and Cosmetics Year:2016 | Volume:7 | Issue:1 Page(s): 1-9

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Title

EFFICACY OF LICORICE EXTRACT IN THE TREATMENT OF MELASMA: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL

Author(s)

SHAMSI MEYMANDI SIMIN | MOHAMADZADEH SHANEHSAZ SIAVASH | ANSARI DOGAHEH MEHDI | JAHANI YUNES | Issue Writer Certificate

Keywords

MELASMAQ3

LICORICE EXTRACTQ1

CLINICAL TRIALQ3

SOLID LIPID NANOPARTICLESQ1

Abstract

Background and Aim: MELASMA is a common acquired disorder characterized by symmetric, hyperpigmented patches with an irregular outline, occurring most commonly on the face. The goal of this study was to evaluate the efficacy of a cream containing 4% LICORICE EXTRACT with a novel formulation based on SOLID LIPID NANOPARTICLES technology in the treatment of MELASMA. To the best of our knowledge, it is the first study designed to investigate the efficacy of this novel formulation in the treatment of MELASMA all over the world.Methods: In this randomized, double-blind, placebocontrolled CLINICAL TRIAL, 44 women with clinical diagnosis of MELASMA referred to the Afzalipour hospital dermatology clinic were randomly allocated into two treatment groups of equal size. All the patients were interviewed and examined every four weeks during the trial and their Modified MELASMA Area and Severity Index (MMASI) score were evaluated at 4, 8 and 12 weeks. The efficacy of the interventions were classified in four levels: complete response, significant response, partial response and no response.Results: Forty patients were enrolled in the study. At the end of the study (12 weeks), mean ± standard deviation of MMASI score changed from 11.03±2.7 to 1.41±0.6 in the intervention group and from 11.25±2.9 to 2.37±1.2 in the placebo group, respectively (P<0.001).Conclusion: LICORICE EXTRACT can be used as a skin-lightening agent with minimal side effect in the treatment of MELASMA. Nano/micro solid lipid particles are used as carriers with unique properties like size, surface electrical bar. Moreover, a large amount of the drug might be loaded to increase the efficacy and decrease the adverse events.

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References

EVALUATION OF LICORICE EFFICACY ON MELISMA

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APA: Copy

SHAMSI MEYMANDI, SIMIN, MOHAMADZADEH SHANEHSAZ, SIAVASH, ANSARI DOGAHEH, MEHDI, & JAHANI, YUNES. (2016). EFFICACY OF LICORICE EXTRACT IN THE TREATMENT OF MELASMA: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL. DERMATOLOGY AND COSMETIC, 7(1), 1-9. SID. https://sid.ir/paper/157543/en

Vancouver: Copy

SHAMSI MEYMANDI SIMIN, MOHAMADZADEH SHANEHSAZ SIAVASH, ANSARI DOGAHEH MEHDI, JAHANI YUNES. EFFICACY OF LICORICE EXTRACT IN THE TREATMENT OF MELASMA: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL. DERMATOLOGY AND COSMETIC[Internet]. 2016;7(1):1-9. Available from: https://sid.ir/paper/157543/en

IEEE: Copy

SIMIN SHAMSI MEYMANDI, SIAVASH MOHAMADZADEH SHANEHSAZ, MEHDI ANSARI DOGAHEH, and YUNES JAHANI, “EFFICACY OF LICORICE EXTRACT IN THE TREATMENT OF MELASMA: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL,” DERMATOLOGY AND COSMETIC, vol. 7, no. 1, pp. 1–9, 2016, [Online]. Available: https://sid.ir/paper/157543/en

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