TGF-β 1 GENE EXPRESSION IN SKIN LESIONS AND CORRELATION WITH PRURITUS IN MUSTARD GAS EXPOSED VICTIMS

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KHAHESHI ISA; KESHAVARZ SAEED; SHOHRATI MAJID; FOOLADI IMANI ABBASALI; NOURANI MOHAMMAD REZA

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Journal: Dermatology and Cosmetics Year:2011 | Volume:1 | Issue:4 Page(s): 162-171

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Title

TGF-β 1 GENE EXPRESSION IN SKIN LESIONS AND CORRELATION WITH PRURITUS IN MUSTARD GAS EXPOSED VICTIMS

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Keywords

TGF-β 1Q3

CYTOKINEQ3

MUSTARD GASQ3

PRURITUSQ2

Abstract

Background and Aim: As a blistering agent, MUSTARD GAS causes a variety of disorders in different body organs, including the skin, such as altrations in DNA and clinical manifestations like PRURITUS. TGF-β1 molecule is a CYTOKINE with anti-cell growth and inflammation suppression effects in skin inflammation. The aim of this study was to determine TGF-β1 gene exprtession in victims exposed to MUSTARD GAS and the correlation with the severity of their PRURITUS.Methods: 17 victims exposed to MUSTARD GAS, 17 patients with chronic contact dermatitis and 10 healthy individuals were included in the study. The assessment of TGF-β1 expression in their skin samples was conducted by semi-quantitative RT-PCR followed by immunohistochemistry and classification of patients was done by PRURITUS severity scoring system (0-3).Results: There was a significant decrease in TGF-β1 gene expression in MUSTARD GAS exposed victims comparing to chronic contact dermatitis group and the control group (P<0.05). In addition, in the absence of TGF-β1 expression, the severity of PRURITUS in the patient group significantly increased (P<0.05).Conclusion: TGF-β1 has a significant role in chronic inflammatory skin lesions caused by MUSTARD GAS.

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APA: Copy

KHAHESHI, ISA, KESHAVARZ, SAEED, SHOHRATI, MAJID, FOOLADI IMANI, ABBASALI, & NOURANI, MOHAMMAD REZA. (2011). TGF-β 1 GENE EXPRESSION IN SKIN LESIONS AND CORRELATION WITH PRURITUS IN MUSTARD GAS EXPOSED VICTIMS. DERMATOLOGY AND COSMETIC, 1(4), 162-171. SID. https://sid.ir/paper/157585/en

Vancouver: Copy

KHAHESHI ISA, KESHAVARZ SAEED, SHOHRATI MAJID, FOOLADI IMANI ABBASALI, NOURANI MOHAMMAD REZA. TGF-β 1 GENE EXPRESSION IN SKIN LESIONS AND CORRELATION WITH PRURITUS IN MUSTARD GAS EXPOSED VICTIMS. DERMATOLOGY AND COSMETIC[Internet]. 2011;1(4):162-171. Available from: https://sid.ir/paper/157585/en

IEEE: Copy

ISA KHAHESHI, SAEED KESHAVARZ, MAJID SHOHRATI, ABBASALI FOOLADI IMANI, and MOHAMMAD REZA NOURANI, “TGF-β 1 GENE EXPRESSION IN SKIN LESIONS AND CORRELATION WITH PRURITUS IN MUSTARD GAS EXPOSED VICTIMS,” DERMATOLOGY AND COSMETIC, vol. 1, no. 4, pp. 162–171, 2011, [Online]. Available: https://sid.ir/paper/157585/en

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