Evaluation of Glutathione Redox Status and Inflammatory Markers in ICU Patients with Acute Respiratory Syndrome due to COVID-19

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Seifi Skishahr Farnaz; Nabilpour Maghsoud

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Journal Paper

Paper Information

Journal: Jentashapir Journal of Cellular and Molecular Biology Year:2025 | Volume:16 | Issue:2 Page(s): 1-8

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Information Journal Paper

Title

Evaluation of Glutathione Redox Status and Inflammatory Markers in ICU Patients with Acute Respiratory Syndrome due to COVID-19

Author(s)

Seifi Skishahr Farnaz | Nabilpour Maghsoud | Issue Writer Certificate

Keywords

Interleukin-6

Interleukin-10

Glutathione

Cysteine

Abstract

Background: The use of biomarkers may significantly predict the need for special care and mortality risk in patients with COVID-19. Objectives: This study examines the Glutathione redox status, inflammatory markers, and vitamin D levels in hospitalized COVID-19 patients in the intensive care unit (ICU). Methods: A cohort of COVID-19 patients (n = 16) was compared to a healthy control group. Levels of reduced Glutathione (GSH), oxidized Glutathione (GSSG), C-reactive protein (CRP), Interleukin-10 (IL-10), Interleukin-6 (IL-6), Cysteine, cystine, and vitamin D were measured using enzyme-linked immunosorbent assay (ELISA). Independent t-tests and Cohen's d were employed to analyze differences. Results: COVID-19 patients exhibited significant differences from healthy controls in all measured indicators, including GSH, GSSG, CRP, IL-10, IL-6, Cysteine, cystine, and the GSH/GSSG ratio (P ≤ 0.001). Additionally, all patients demonstrated vitamin D deficiency, with levels ranging from 10 to 20 ng/dL. Ratios of GSH to GSSG, IL-6 to IL-10, and CRP to Cysteine also indicated significant differences between COVID-19 patients and healthy controls (P ≤ 0.001). Conclusions: Measurement of Glutathione redox indicators, IL-6 and IL-10 levels, and their respective ratios, along with vitamin D and Cysteine/cystine levels, could serve as effective predictors for timely interventions in COVID-19 patients hospitalized in the ICU.

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