EVALUATION OF LAVANDULA OFFICINALIS EXTRACT ON LYMPHOCYTE PROLIFERATION AND TUMOR NECROSIS FACTOR-ALPHA PRODUCTION

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AZADMEHR A.; HAJIAGHAEE R.; REZAZADEH SH.; AFSHARI A.; KIANI AMIN M.; BARADARAN B.; EBRAHIMI P.

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Journal: Journal of Medicinal Plants Year:2011 | Volume:10 | Issue:38 Page(s): 142-147

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Title

EVALUATION OF LAVANDULA OFFICINALIS EXTRACT ON LYMPHOCYTE PROLIFERATION AND TUMOR NECROSIS FACTOR-ALPHA PRODUCTION

Author(s)

Keywords

LAVANDULA OFFICINALISQ2

LYMPHOCYTE PROLIFERATIONQ3

TUMOR NECROSIS FACTOR ALPHAQ3

Abstract

Background: Studies have demonstrated that plant extracts have various biological effects including immunomodulatory effect.Objective: In the present study, the immunomodulatory effects of LAVANDULA OFFICINALIS on LYMPHOCYTE PROLIFERATION and TUMOR NECROSIS FACTOR ALPHA cytokine production were investigated.Methods: [3H]-thymidine incorporation assay on stimulation of the peripheral lymphocytes with PHA and determination of TUMOR NECROSIS FACTOR ALPHA production was assayed, using LISA method.Results: The herbal extract in a concentration of 50 mg/ml and lesser, in the presence of mitogen increased peripheral blood lymphocytes proliferation. However, there was not significant effect in concentrations more than 50 mg/ml. Also, the extract in the concentration of higher than 50 mg/ml suppressed the production of TUMOR NECROSIS FACTOR ALPHA in the exposed cells.Conclusion: The extract showed immunomodulatory effect by increasing of LYMPHOCYTE PROLIFERATION in a concentration of 50 mg/ml and lesser. Also, decreasing in TUMOR NECROSIS FACTOR ALPHA in the concentration of more than 50 mg/ml was observed. Further studies, should focus on identifying the immunomodulatory mediator of this herbal extract.

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APA: Copy

AZADMEHR, A., HAJIAGHAEE, R., REZAZADEH, SH., AFSHARI, A., KIANI AMIN, M., BARADARAN, B., & EBRAHIMI, P.. (2011). EVALUATION OF LAVANDULA OFFICINALIS EXTRACT ON LYMPHOCYTE PROLIFERATION AND TUMOR NECROSIS FACTOR-ALPHA PRODUCTION. JOURNAL OF MEDICINAL PLANTS, 10(38), 142-147. SID. https://sid.ir/paper/15768/en

Vancouver: Copy

AZADMEHR A., HAJIAGHAEE R., REZAZADEH SH., AFSHARI A., KIANI AMIN M., BARADARAN B., EBRAHIMI P.. EVALUATION OF LAVANDULA OFFICINALIS EXTRACT ON LYMPHOCYTE PROLIFERATION AND TUMOR NECROSIS FACTOR-ALPHA PRODUCTION. JOURNAL OF MEDICINAL PLANTS[Internet]. 2011;10(38):142-147. Available from: https://sid.ir/paper/15768/en

IEEE: Copy

A. AZADMEHR, R. HAJIAGHAEE, SH. REZAZADEH, A. AFSHARI, M. KIANI AMIN, B. BARADARAN, and P. EBRAHIMI, “EVALUATION OF LAVANDULA OFFICINALIS EXTRACT ON LYMPHOCYTE PROLIFERATION AND TUMOR NECROSIS FACTOR-ALPHA PRODUCTION,” JOURNAL OF MEDICINAL PLANTS, vol. 10, no. 38, pp. 142–147, 2011, [Online]. Available: https://sid.ir/paper/15768/en

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