Inhibition of Heme Polymerization, the Mechanism of Antimalarial Activity in Phlomis caucasica Rech. f. (Lamiaceae)

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Esmaeili Somayyeh; Irani Mahboobeh; Moazzeni Hamid; MOSADDEGH MAHMOOD

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Journal: Journal of Medicinal Plants Year:2019 | Volume:18 | Issue:SUPPLEMENT 12 Page(s): 103-109

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Information Journal Paper

Title

Inhibition of Heme Polymerization, the Mechanism of Antimalarial Activity in Phlomis caucasica Rech. f. (Lamiaceae)

Author(s)

Esmaeili Somayyeh | Irani Mahboobeh | Moazzeni Hamid | MOSADDEGH MAHMOOD | Issue Writer Certificate

Keywords

Phlomis caucasicaQ1

Inhibition of heme polymerizationQ1

LamiaceaeQ1

MalariaQ1

Abstract

Background: Malaria is one of the most important parasitic diseases in the world caused by Plasmodium species. The Malaria parasite digests hemoglobin in vacuole to amino acids and heme. Plasmodium has got several detoxification mechanisms to protect itself from toxic heme. The most important mechanism is heme polymerization. Identifying compounds that inhibit heme polymerization is an approach for detecting antiMalarial drugs. Objective: This work has intended to screen some plants from Lamiaceae family for mechanism of antiMalarial by ITHD (Inhibition Test of Heme Detoxification). Method: Inhibition of heme polymerization of total methanol extracts from seven plants of Lamiaceae family have been evaluated by the ITHD method. Hemin Chloride, tween 20 and samples were added in each well of a 96-well plate with ratio 9: 9: 2, and incubated at 60º C for 24 h. The plate was read with a micro-ELISA reader at 405 nm, and percentage of heme polymerization inhibition was calculated. The fractions including petroleum ether, chloroform, methanol, methanol: water (7: 3) and water were obtained by maceration and the Inhibition of heme polymerization evaluation were assessed using the ITHD. Results: Total methanol extracts of Marrubium astracanicum Jacq. and Phlomis caucasica Rech. f. demonstrated Inhibition of heme polymerization, 40 and 35% respectively. The aqueous fraction of P. caucasica inhibited heme polymerization 100%. Conclusion: P. caucasica could be a selective candidate for drug discovery program in Malaria.

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References

Inhibition Test of Heme Detoxification (ITHD) as an Approach for Detecting Antimalarial Agents in Medicinal Plants

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APA: Copy

Esmaeili, Somayyeh, Irani, Mahboobeh, Moazzeni, Hamid, & MOSADDEGH, MAHMOOD. (2019). Inhibition of Heme Polymerization, the Mechanism of Antimalarial Activity in Phlomis caucasica Rech. f. (Lamiaceae). JOURNAL OF MEDICINAL PLANTS, 18(SUPPLEMENT 12 ), 103-109. SID. https://sid.ir/paper/15900/en

Vancouver: Copy

Esmaeili Somayyeh, Irani Mahboobeh, Moazzeni Hamid, MOSADDEGH MAHMOOD. Inhibition of Heme Polymerization, the Mechanism of Antimalarial Activity in Phlomis caucasica Rech. f. (Lamiaceae). JOURNAL OF MEDICINAL PLANTS[Internet]. 2019;18(SUPPLEMENT 12 ):103-109. Available from: https://sid.ir/paper/15900/en

IEEE: Copy

Somayyeh Esmaeili, Mahboobeh Irani, Hamid Moazzeni, and MAHMOOD MOSADDEGH, “Inhibition of Heme Polymerization, the Mechanism of Antimalarial Activity in Phlomis caucasica Rech. f. (Lamiaceae),” JOURNAL OF MEDICINAL PLANTS, vol. 18, no. SUPPLEMENT 12 , pp. 103–109, 2019, [Online]. Available: https://sid.ir/paper/15900/en

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