The effect of exercise training on vaspin serum levels in obese individuals and type 2 diabetes patients: a meta-analysis study

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Rahimi Mohammad Rahman; Faraji Hassan; Samzadeh Kermani Fataneh

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Journal Paper

Paper Information

Journal: JOURNAL OF SPORT AND EXERCISE PHYSIOLOGY Year:2025 | Volume:18 | Issue:1 Page(s): 102-124

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Title

The effect of exercise training on vaspin serum levels in obese individuals and type 2 diabetes patients: a meta-analysis study

Author(s)

Rahimi Mohammad Rahman | Faraji Hassan | Samzadeh Kermani Fataneh | Issue Writer Certificate

Keywords

Physical Training

Aerobic training

Resistance training

Serpin Derived From Visceral Fat Tissue

Abstract

Background and Purpose: Vaspin (serpin derived from visceral adipose tissue) is an adipokine secreted from adipose tissue that plays a role in regulating glucose and lipid metabolism. Elevated vaspin levels are associated with obesity, metabolic syndrome, and type 2 diabetes (T2DM). The effect of regular sports training on its levels is not known.Materials and Methods: All randomized controlled clinical trials from 2000 to 2023 that performed aerobic, resistance and HIIT exercise training on the vaspin index in obese and T2DM subjects were systemically searched and selected through databases including WOS, PubMed and Google Scholar. In the initial search, 560 articles related to the topic were found and finally, based on the criteria, 20 articles were selected for meta-analysis. The random effects model was used in the case of heterogeneity between studies and the fixed effects model in the absence of heterogeneity was used to calculate the effect size. A significance level of p<0.05 was considered and data analysis was performed by CMA 3.0 software.Results: The meta-analysis results indicated a significant decrease in vaspin levels due to exercise training with an effect size of SMD=-0.260 and a 95% confidence interval of -0.517 to -0.002 (p=0.048). Also, resistance training (SMD=-0.674, 95% CL=-1.021; -0.327, p=0.001) was associated with a significant decrease in vaspin. However, vaspin changes were not significant after aerobic and HIIT exercise training protocols. In the subgroup analysis, age, gender and type of disease (obese or T2DM) had no significant effect on the effect of training on vaspin, but BMI (p=0.005, SMD =-0.384) and type of exercise (p=0.001, SMD =-0.396) had a significant effect in terms of the reduction of vaspin, the largest reduction was related to BMI 25 to 30, and the reduction of vaspin due to resistance training was more than other exercises.Conclusion: The general finding of the present meta-analysis indicates a significant decrease in circulating vaspin levels in obese individuals with T2DM as a result of training. Meanwhile, in relation to the type of training, only performing resistance training caused a significant decrease in vaspin levels, and individuals with a BMI between 25 and 30 have experienced a greater decrease in vaspin levels following performing resistance training. The subgroups analysis did not show a significant effect of training on the level of vaspin. More accurate randomized controlled studies are needed to investigate the effect of training type, especially aerobic and HIIT training and different exercise variables in individuals with other health conditions.

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