EFFICIENCY OF ROTATIONAL AND SWING TESTS IN EVALUATION OF MORE ASYMMETRY IN HEMIPARKINSONIAN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ROUGHANI M.; BEHZADY G.; BALUCHNEJADMOJARAD TOURANDOKHT

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2002 | Volume:4 | Issue:13 Page(s): 41-45

Download Full-Text

Persian Verion

View:

2,039

Download:

Cites:

Information Journal Paper

Title

EFFICIENCY OF ROTATIONAL AND SWING TESTS IN EVALUATION OF MORE ASYMMETRY IN HEMIPARKINSONIAN RATS

Author(s)

ROUGHANI M. | BEHZADY G. | BALUCHNEJADMOJARAD TOURANDOKHT | Issue Writer Certificate

Keywords

SWING TESTQ3

ROTATIONAL BEHAVIORQ3

PARKINSON’S DISEASEQ4

6-HYDROXYDOPAMINEQ4

RATQ3

Abstract

Introduction: Animal models of PARKINSON’S DISEASE (PD) with partial damage of nigrostriatal dopaminergic system are very suitable for development of treatment strategies. Although drug-induced ROTATIONAL BEHAVIOR has been conventionally used for analysis of lesioned animals, but bcause of the development of sensitization, it is necessary to invent a pure behavioral test that can evaluate such animals in a drug-free state which may better reflect a more natural response of the animal following lesion. This study was conducted to evaluate the efficiency of elevated-body SWING TEST in analysis of unilaterally lesioned animals in an early model of PARKINSON’S DISEASE. Material and Methods: Thirty male RATs were randomly divided into sham-operated and lesion groups. An early model of PD was developed by interstitial injection of 12.2 μg of 6-HYDROXYDOPAMINE (6-OHDA) into the left striatum. Apomorphine-induced rotational and drug-free elevated body swing behaviors were evaluated. Results: Results of behavioral tests revealed that apomorphine caused a very significant contralateral turning in the RATs of the lesion group (L+V) compared to sham-operated group (SH) (P<0.0001). In addition, there existed a significant difference between +V and SH groups in the second (P<0.01) and fourth weeks (P<0.05) after surgery. Further analysis of correlation for not number of rotations versus net number of rotations versus net number swings revealed a significant and positive correlation (r=0.52) in the second week in L+V group, but no such correlation was observed in the fourth week (r=0.24). Conclusion: Taken together, it is concluded that elevated body SWING TEST may be of less value in evaluation of motor asymmetry in an early model of PARKINSON’S DISEASE compared to drug-induced ROTATIONAL BEHAVIOR. Therefore, it may be used as a complementary test to drug-induced rotational test for alternate evaluation of motor asymmetry in unilateral model of early PD in RATs.

Cites

No record.

References

Cite

APA: Copy

ROUGHANI, M., BEHZADY, G., & BALUCHNEJADMOJARAD, TOURANDOKHT. (2002). EFFICIENCY OF ROTATIONAL AND SWING TESTS IN EVALUATION OF MORE ASYMMETRY IN HEMIPARKINSONIAN RATS . CELL JOURNAL (YAKHTEH), 4(13), 41-45. SID. https://sid.ir/paper/16178/en

Vancouver: Copy

ROUGHANI M., BEHZADY G., BALUCHNEJADMOJARAD TOURANDOKHT. EFFICIENCY OF ROTATIONAL AND SWING TESTS IN EVALUATION OF MORE ASYMMETRY IN HEMIPARKINSONIAN RATS . CELL JOURNAL (YAKHTEH)[Internet]. 2002;4(13):41-45. Available from: https://sid.ir/paper/16178/en

IEEE: Copy

M. ROUGHANI, G. BEHZADY, and TOURANDOKHT BALUCHNEJADMOJARAD, “EFFICIENCY OF ROTATIONAL AND SWING TESTS IN EVALUATION OF MORE ASYMMETRY IN HEMIPARKINSONIAN RATS ,” CELL JOURNAL (YAKHTEH), vol. 4, no. 13, pp. 41–45, 2002, [Online]. Available: https://sid.ir/paper/16178/en

Related Journal Papers