MOLECULAR ANALYSIS OF HS-111 AND 3`HS1 VARIATIONS IN β-THALASSEMIA INTERMEDIA PATIENTS WITH HIGH LEVELS OF HBF

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HAMID M.; KARIMIPOUR MOJTABA; ZEYNALI SIROUS; AKBARI M.T.; KOUKABI L.; MAHJOUBI F.

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Title

MOLECULAR ANALYSIS OF HS-111 AND 3`HS1 VARIATIONS IN β-THALASSEMIA INTERMEDIA PATIENTS WITH HIGH LEVELS OF HBF

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Keywords

β-THALASSEMIAQ1

FETAL HAEMOGLOBINQ1

SINGLE-STRAND CONFIRMATION POLYMORPHISMQ1

Abstract

Objective: To study the possible association between high levels of FETAL HAEMOGLOBIN (HbF) in b-thalassemia intermedia patients and HS-111 and 3`HS1 sequence variations.Materials and Methods: In this study, the 3' HS-1 and HS-111 regions of 30 b-thalassaemia intermedia patients (bo/bo) with high levels of HbF, 21 b-thalassemia major patients and 40 normal Iranian individuals were analyzed by single-strand conformation polymorphism (SSCP) and polymerase chain reaction (PCR) sequencing. Results: Two nucleotide variations in 3' HS111 (-21A>G) and 3`HS1 (179C>T) were identified. The most frequent sequence variation was 3' HS111 (-21A) in the intermedia patients and 3`HS111 (-21G) in the major thalassemia patients. In contrast to the 3`HS1 marker, both 3'HS111 A and G variants showed a correlation with each studied group.Conclusion: The HS111 marker in conjunction with other parameters could be used as appropriate genetic markers to discriminate b-thalassemia intermedia patients (bo/bo) with high levels of HbF from b-thalassemia major patients.

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APA: Copy

HAMID, M., KARIMIPOUR, MOJTABA, ZEYNALI, SIROUS, AKBARI, M.T., KOUKABI, L., & MAHJOUBI, F.. (2010). MOLECULAR ANALYSIS OF HS-111 AND 3`HS1 VARIATIONS IN β-THALASSEMIA INTERMEDIA PATIENTS WITH HIGH LEVELS OF HBF. CELL JOURNAL (YAKHTEH), 11(4 (44)), 418-423. SID. https://sid.ir/paper/16225/en

Vancouver: Copy

HAMID M., KARIMIPOUR MOJTABA, ZEYNALI SIROUS, AKBARI M.T., KOUKABI L., MAHJOUBI F.. MOLECULAR ANALYSIS OF HS-111 AND 3`HS1 VARIATIONS IN β-THALASSEMIA INTERMEDIA PATIENTS WITH HIGH LEVELS OF HBF. CELL JOURNAL (YAKHTEH)[Internet]. 2010;11(4 (44)):418-423. Available from: https://sid.ir/paper/16225/en

IEEE: Copy

M. HAMID, MOJTABA KARIMIPOUR, SIROUS ZEYNALI, M.T. AKBARI, L. KOUKABI, and F. MAHJOUBI, “MOLECULAR ANALYSIS OF HS-111 AND 3`HS1 VARIATIONS IN β-THALASSEMIA INTERMEDIA PATIENTS WITH HIGH LEVELS OF HBF,” CELL JOURNAL (YAKHTEH), vol. 11, no. 4 (44), pp. 418–423, 2010, [Online]. Available: https://sid.ir/paper/16225/en

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