CALCIUM SIGNALING PATHWAYS INVOLVED IN LONG-TERM POTENTIATION AT EXCITATORY SYNAPSES ON PARVALBUMIN POSITIVE FAST-SPIKING GABAERGIC NEURONS IN THE MOUSE VISUAL CORTEX

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SARIHI A.A.R.; KOMAKI A.R.; TSUMOTO T.

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Paper Information

Journal: Cell Journal (Yakhteh) Year:2009 | Volume:11 | Issue:3 (43) Page(s): 285-292

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Title

CALCIUM SIGNALING PATHWAYS INVOLVED IN LONG-TERM POTENTIATION AT EXCITATORY SYNAPSES ON PARVALBUMIN POSITIVE FAST-SPIKING GABAERGIC NEURONS IN THE MOUSE VISUAL CORTEX

Author(s)

SARIHI A.A.R. | KOMAKI A.R. | TSUMOTO T. | Issue Writer Certificate

Keywords

GABAQ1

LONG-TERM POTENTIATIONQ1

VISUAL CORTEXQ1

METABOTROPIC GLUTAMATE RECEPTORQ1

CALCIUM SIGNALINGQ1

Abstract

Objective: Recently, we reported the presence of METABOTROPIC GLUTAMATE RECEPTOR type 5 (mGluR-5) dependent LONG-TERM POTENTIATION (LTP) at excitatory synapses on fast-spiking GABAergic (FS-GABA) cells in the VISUAL CORTEX. In this study, we report a Ca2+ signaling pathway involved in this LTP type.Materials and Methods: Brain slices from GAD67-GFP knock-in mice were used. Using whole-cell patch-clamp recording followed by immunohistochemical staining on parvalbumin- positive (PV+) FS-GABA cells, we studied the Ca2+ signaling pathway involved in excitatory LTP of certain visual cortical interneuron subtypes.Results: U-73122- a phospolipas c (PLC) inhibitor (10mM), inositol triphosphate (IP3) inhibitors such as 2-APB (3mM) and heparin (10IU/ml), and CPA- the internally stored Ca2+ release inhibitor- (5mM) blocked the mGluR5 signaling pathway to induce LTP at excitatory synapses on PV+ fast-spiking cells in the VISUAL CORTEX. However, application of the vehicles alone had no effect.Conclusion: Our results indicate that mGluR-5 at FS-GABA neurons activate PLC and IP3 production. This leads to Ca2+ release, promotes LTP induction, and its maintenance is supported by internal Ca2+ stores. Considering the key role of PV+ FS inhibitory neurons in the VISUAL CORTEX circuits, we suggest that the METABOTROPIC GLUTAMATE RECEPTOR-dependent LTP of excitatory synapses to FS cells plays a crucial role in the VISUAL CORTEX plasticity.

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APA: Copy

SARIHI, A.A.R., KOMAKI, A.R., & TSUMOTO, T.. (2009). CALCIUM SIGNALING PATHWAYS INVOLVED IN LONG-TERM POTENTIATION AT EXCITATORY SYNAPSES ON PARVALBUMIN POSITIVE FAST-SPIKING GABAERGIC NEURONS IN THE MOUSE VISUAL CORTEX. CELL JOURNAL (YAKHTEH), 11(3 (43)), 285-292. SID. https://sid.ir/paper/16258/en

Vancouver: Copy

SARIHI A.A.R., KOMAKI A.R., TSUMOTO T.. CALCIUM SIGNALING PATHWAYS INVOLVED IN LONG-TERM POTENTIATION AT EXCITATORY SYNAPSES ON PARVALBUMIN POSITIVE FAST-SPIKING GABAERGIC NEURONS IN THE MOUSE VISUAL CORTEX. CELL JOURNAL (YAKHTEH)[Internet]. 2009;11(3 (43)):285-292. Available from: https://sid.ir/paper/16258/en

IEEE: Copy

A.A.R. SARIHI, A.R. KOMAKI, and T. TSUMOTO, “CALCIUM SIGNALING PATHWAYS INVOLVED IN LONG-TERM POTENTIATION AT EXCITATORY SYNAPSES ON PARVALBUMIN POSITIVE FAST-SPIKING GABAERGIC NEURONS IN THE MOUSE VISUAL CORTEX,” CELL JOURNAL (YAKHTEH), vol. 11, no. 3 (43), pp. 285–292, 2009, [Online]. Available: https://sid.ir/paper/16258/en

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