A STUDY ON THE ANTI-OXIDANT EFFECTS OF EUGENOL ON RETINOIC ACID TOXICITY IN WHITE MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AMINI A.; MIR MOUMENI M.H.; CHERAGHI E.; GHAMARY E.; POURMOTEABED A.R.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2001 | Volume:2 | Issue:8 Page(s): 203-207

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,063

Download:

Cites:

Information Journal Paper

Title

A STUDY ON THE ANTI-OXIDANT EFFECTS OF EUGENOL ON RETINOIC ACID TOXICITY IN WHITE MICE

Author(s)

Keywords

RETINOIC ACIDQ2

EUGENOLQ4

TOXICITYQ4

ANTIOXIDANTQ4

Abstract

Introduction: RETINOIC ACID (RA), one of the synthetic vitamin A derivative which has been frequently used as a drug to treat face acne, is know to have specific side effects on the testis, liver, spleen and etc. Therefore, we have tried to find a compound which would decrease its side effects. EUGENOL is a compound extracted from Clove tree. It has anti-anaphylactic, anti-inflammation, antiseptic properties and inhibits lipid peroxidation by acting as a chain breaking ANTIOXIDANT. In trying to find an antagonistic angent for RA, we have used EUGENOL. Material and Methods: In this research, we have chosen 6 weeks old male mice of NMRI strain weighting 26?2 grams. The mice were divided into five experimental groups. The first group were fed only with normal diet (as control)1, but the other four groups were fed with normal diet plus olive oil (as Solvent) 2, (Retionic acid)3, (Eugenol) 4 and (Eugenol+RETINOIC ACID) 5. We administered 100 mg/kg of EUGENOL and 30 mg/kg of retionic acid for eight days. Following dissection of mice and collection blood various parameters including cholesterol. Triglyceride, LDH and ALP were analyzed.Results: Results obtained from these experiment indicated that RA increased the amount of cholesterol and triglyceride by 23.3% (P<0.001) and 13.4% (P<0.01) respectively compared with the control group. Similarly, the amount of LDH and ALP activity enzymes occuring in blood plasma increased by 25.8% & 42.4% (P<0.001) respectively compared with solvent group (Control). Dietary uptake of EUGENOL has decreased the amount of cholesterol and triglyceride by 15.9% (P<0.001) and 12.3% (P<0.01) respectively. Mice were adminstered with dietary EUGENOL have demonestered a marked decreased in LDH and ALP activities by 13.7% (P<0.01) and 16.4% (P<0.05) respectively. Conclusion: It was obsereved that the cytotoxicity of retionic acid had been decreased markedly by EUGENOL. Therefore, the ANTIOXIDANT role of EUGENOL can decrease the side effects of retionic acid. It can be concluded that EUGENOL can be used to alleviate side effect of RA.

Cites

No record.

References

Cite

APA: Copy

AMINI, A., MIR MOUMENI, M.H., CHERAGHI, E., GHAMARY, E., & POURMOTEABED, A.R.. (2001). A STUDY ON THE ANTI-OXIDANT EFFECTS OF EUGENOL ON RETINOIC ACID TOXICITY IN WHITE MICE . CELL JOURNAL (YAKHTEH), 2(8), 203-207. SID. https://sid.ir/paper/16312/en

Vancouver: Copy

AMINI A., MIR MOUMENI M.H., CHERAGHI E., GHAMARY E., POURMOTEABED A.R.. A STUDY ON THE ANTI-OXIDANT EFFECTS OF EUGENOL ON RETINOIC ACID TOXICITY IN WHITE MICE . CELL JOURNAL (YAKHTEH)[Internet]. 2001;2(8):203-207. Available from: https://sid.ir/paper/16312/en

IEEE: Copy

A. AMINI, M.H. MIR MOUMENI, E. CHERAGHI, E. GHAMARY, and A.R. POURMOTEABED, “A STUDY ON THE ANTI-OXIDANT EFFECTS OF EUGENOL ON RETINOIC ACID TOXICITY IN WHITE MICE ,” CELL JOURNAL (YAKHTEH), vol. 2, no. 8, pp. 203–207, 2001, [Online]. Available: https://sid.ir/paper/16312/en

Related Journal Papers