EFFECT OF ADENOSINE A1 RECERTORS OF AMYGDALA ON ENTORHINAL CORTEX KINDLED SEIZURES IN RAT

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AMINI KOMIJANI A.; MIRNAJAFIZADEH S.J.; FATH ELAHI Y.; MOTAMEDI F.

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Journal: Cell Journal (Yakhteh) Year:2003 | Volume:5 | Issue:19 Page(s): 137-143

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Information Journal Paper

Title

EFFECT OF ADENOSINE A1 RECERTORS OF AMYGDALA ON ENTORHINAL CORTEX KINDLED SEIZURES IN RAT

Author(s)

AMINI KOMIJANI A. | MIRNAJAFIZADEH S.J. | FATH ELAHI Y. | MOTAMEDI F. | Issue Writer Certificate

Keywords

SEIZUREQ3

ADENOSINEQ3

AMYGDALAQ3

ENTORHINAL CORTEXQ3

KINDLINGQ3

Abstract

Introduction: The role of ADENOSINE A1 receptors of the AMYGDALA on ENTORHINAL CORTEX kindled SEIZUREs was investigated. Material and Methods: Animals were kindled by daily electrical stimutation of ENTORHINAL CORTEX. In the full kindled animals, N6-cyclohexyladenosine (CHA 10, 50, 100, 500َM), an ADENOSINE A1 receptor agonist and 8-cyclopentyl- 1, 3, dimethylxanthine (CPT, 10, 20 َM), an ADENOSINE A1 receptor antagonist, were microinfused into the AMYGDALA. Results: Data showed that CHA, only at a concentration of 500َM, decreaed ENTORHINAL CORTEX and AMYGDALA after discharge duration, stage 5 duration and SEIZURE duration SEIZURE duration and increased patency to stage 4 at 15 min post drug injection. Intraamygdala injection of CPT showed that it only at a concentration of 20 َM, reduced patency to stage 4. Intraamygdala pretreatment of animals by intraamygdala injection of CPT (10 َM), 5 min before CHA (500 َM), resulted in blockage of anticonvulsant effects of CHA. Conclusion: These results suggest that the AMYGDALA may have a moderate role in SEIZURE propagation from the ENTORHINAL CORTEX and its ADENOSINE A1 receptor activity has anticovulsant effects on ENTORHINAL CORTEX kindled SEIZUREs.

Cites

ADENOSINE A1 RECEPTORS OF AMYGDALA HAS NOT ANTICONVULSANT EFFECTS ON PIRIFORM CORTEX KINDLED SEIZURES IN RATS

References

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APA: Copy

AMINI KOMIJANI, A., MIRNAJAFIZADEH, S.J., FATH ELAHI, Y., & MOTAMEDI, F.. (2003). EFFECT OF ADENOSINE A1 RECERTORS OF AMYGDALA ON ENTORHINAL CORTEX KINDLED SEIZURES IN RAT . CELL JOURNAL (YAKHTEH), 5(19), 137-143. SID. https://sid.ir/paper/16339/en

Vancouver: Copy

AMINI KOMIJANI A., MIRNAJAFIZADEH S.J., FATH ELAHI Y., MOTAMEDI F.. EFFECT OF ADENOSINE A1 RECERTORS OF AMYGDALA ON ENTORHINAL CORTEX KINDLED SEIZURES IN RAT . CELL JOURNAL (YAKHTEH)[Internet]. 2003;5(19):137-143. Available from: https://sid.ir/paper/16339/en

IEEE: Copy

A. AMINI KOMIJANI, S.J. MIRNAJAFIZADEH, Y. FATH ELAHI, and F. MOTAMEDI, “EFFECT OF ADENOSINE A1 RECERTORS OF AMYGDALA ON ENTORHINAL CORTEX KINDLED SEIZURES IN RAT ,” CELL JOURNAL (YAKHTEH), vol. 5, no. 19, pp. 137–143, 2003, [Online]. Available: https://sid.ir/paper/16339/en

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