CENTRAL NERVOUS SYSTEM PROTEOMICS IN ANIMAL MODEL OF MULTIPLE SCLEROSIS REVEALED DOWN-REGULATION OF MITHOCHONDRIAL PROTEINS

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SHAHZADEH FAZELI S.A.A.H.; SANATI M.H.; NASRABADI D.; POUYA A.; BAHARVAND HOSSEIN; HOSSEINI SALKADEH S.GH.

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Journal: Cell Journal (Yakhteh) Year:2009 | Volume:11 | Issue:2 (42) Page(s): 236-243

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Title

CENTRAL NERVOUS SYSTEM PROTEOMICS IN ANIMAL MODEL OF MULTIPLE SCLEROSIS REVEALED DOWN-REGULATION OF MITHOCHONDRIAL PROTEINS

Author(s)

Keywords

MITOCHONDRIAQ1

PROTEOMICSQ1

EAEQ1

MULTIPLE SCLEROSISQ1

Abstract

Objective: Detection of central nervous system (CNS) molecular defects in an animal model of MULTIPLE SCLEROSIS.Materials and Methods: Experimental autoimmune encephalomyelitis (EAE) was induced by a myelin oligodendrocyte glycoprotein. Protein expression profiles in the central nervous system between healthy clinical scores 1 and 3 of EAE were studied using a two dimensional electrophoresis based PROTEOMICS approach coupled with MALDI TOF/TOF mass spectrometry.Results: We identified 8 MITOCHONDRIAl proteins that were differentially expressed in CNS, all of them down-regulated in scores 1 and/or 3. Of these, 5 proteins belong to the MITOCHONDRIAl respiratory chain including: NADH dehydrogenase (ubiquinone) Fe-S protein 8, cytochrome c oxidase Va, cytochrome c oxidase Vb, ATP5B, NADH dehydrogenase (ubiquinone) flavoprotein 2. We also observed down-regulation of three other MITOCHONDRIAl proteins including: glutaredoxin 5, estradiol 17 beta-dehydrogenase 8 and isocitrate dehydrogenase.Conclusion: Down-regulation of MITOCHONDRIAl proteins supported the hypothesis that hypoxia-like tissue injury in MULTIPLE SCLEROSIS (MS) lesions may be due to MITOCHONDRIAl impairment.

Cites

COMPARATIVE PROTEOMIC ANALYSIS OF TUMOR MESENCHYMAL-LIKE STEM CELLS DERIVED FROM HIGH GRADE VERSUS LOW GRADE GLIOMAS

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APA: Copy

SHAHZADEH FAZELI, S.A.A.H., SANATI, M.H., NASRABADI, D., POUYA, A., BAHARVAND, HOSSEIN, & HOSSEINI SALKADEH, S.GH.. (2009). CENTRAL NERVOUS SYSTEM PROTEOMICS IN ANIMAL MODEL OF MULTIPLE SCLEROSIS REVEALED DOWN-REGULATION OF MITHOCHONDRIAL PROTEINS. CELL JOURNAL (YAKHTEH), 11(2 (42)), 236-243. SID. https://sid.ir/paper/16402/en

Vancouver: Copy

SHAHZADEH FAZELI S.A.A.H., SANATI M.H., NASRABADI D., POUYA A., BAHARVAND HOSSEIN, HOSSEINI SALKADEH S.GH.. CENTRAL NERVOUS SYSTEM PROTEOMICS IN ANIMAL MODEL OF MULTIPLE SCLEROSIS REVEALED DOWN-REGULATION OF MITHOCHONDRIAL PROTEINS. CELL JOURNAL (YAKHTEH)[Internet]. 2009;11(2 (42)):236-243. Available from: https://sid.ir/paper/16402/en

IEEE: Copy

S.A.A.H. SHAHZADEH FAZELI, M.H. SANATI, D. NASRABADI, A. POUYA, HOSSEIN BAHARVAND, and S.GH. HOSSEINI SALKADEH, “CENTRAL NERVOUS SYSTEM PROTEOMICS IN ANIMAL MODEL OF MULTIPLE SCLEROSIS REVEALED DOWN-REGULATION OF MITHOCHONDRIAL PROTEINS,” CELL JOURNAL (YAKHTEH), vol. 11, no. 2 (42), pp. 236–243, 2009, [Online]. Available: https://sid.ir/paper/16402/en

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