RESPONSIVENESS OF PGI NEURONS TO THE NOXIOUS STIMULUS IN CAPSAICIN TREATED MORPHINE DEPENDENT RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ROHAMPOUR K.; SEMNANIAN S.; FATH ELAHI F.; AZIZI H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2006 | Volume:8 | Issue:1 (29) Page(s): 31-38

Download Full-Text

Persian Verion

View:

1,202

Download:

Cites:

Information Journal Paper

Title

RESPONSIVENESS OF PGI NEURONS TO THE NOXIOUS STIMULUS IN CAPSAICIN TREATED MORPHINE DEPENDENT RATS

Author(s)

ROHAMPOUR K. | SEMNANIAN S. | FATH ELAHI F. | AZIZI H. | Issue Writer Certificate

Keywords

NUCLEUS RETICULARIS PARAGIGANTOCELLULARIS (PGI)Q2

SINGLE UNIT EXTRACELLULAR RECORDINGQ2

CAPSAICIN TREATMENTQ2

PAIN MODULATING PATHWAYSQ2

NOXIOUS STIMULUSQ2

Abstract

Introduction: Nucleus reticularis paragigantocellularis (PGi) is one of the major components of the rostral ventromedial medulla (RVM), which is involved in nociceptive processing and pain modulation. The aim of this study was to examine the effect of C fiber destruction on responsiveness of nucleus reticularis paragigantocellularis (PGi) to formalin, as a NOXIOUS STIMULUS, in normal and morphine dependent rats. Material and Methods: C-fiber destruction was induced by neonatal capsaicin (CAP) treatment (50 mg/Kg, s.c.), in the second postnatal day. Extracellular single unit recording was used in control, capsaicin treated and morphine dependent, urethane (1.2-1.5 g/Kg) anesthetized rats. After baseline recording (40 min), 100µl formalin (5%) was injected into the controlateral hind paw and recording was continued in the PGi, for 60 min after NOXIOUS STIMULUS. Results: In control rats three types of neurons were detected, which were categorized as, increased (38.45%), decreased (23.1%) and neutral neurons (38.45%). In CAP treated rats the 3 types of neurons were observed, too. The duration of response (Baseline ± 2SD), in CAP treated rats was significantly shorter than that of controls. All recorded neurons in morphine dependent rats were neutral, but 30% of recorded neurons in CAP treated morphine dependent rats showed short increase in firing rate.Conclusion: It was concluded that C-fiber destruction may just reduce the time course of changes in firing rate in response to peripheral NOXIOUS STIMULUS, while chronic morphine exposure may suppress the neuronal responsiveness, totally.

Cites

No record.

References

Cite

APA: Copy

ROHAMPOUR, K., SEMNANIAN, S., FATH ELAHI, F., & AZIZI, H.. (2006). RESPONSIVENESS OF PGI NEURONS TO THE NOXIOUS STIMULUS IN CAPSAICIN TREATED MORPHINE DEPENDENT RATS. CELL JOURNAL (YAKHTEH), 8(1 (29)), 31-38. SID. https://sid.ir/paper/16467/en

Vancouver: Copy

ROHAMPOUR K., SEMNANIAN S., FATH ELAHI F., AZIZI H.. RESPONSIVENESS OF PGI NEURONS TO THE NOXIOUS STIMULUS IN CAPSAICIN TREATED MORPHINE DEPENDENT RATS. CELL JOURNAL (YAKHTEH)[Internet]. 2006;8(1 (29)):31-38. Available from: https://sid.ir/paper/16467/en

IEEE: Copy

K. ROHAMPOUR, S. SEMNANIAN, F. FATH ELAHI, and H. AZIZI, “RESPONSIVENESS OF PGI NEURONS TO THE NOXIOUS STIMULUS IN CAPSAICIN TREATED MORPHINE DEPENDENT RATS,” CELL JOURNAL (YAKHTEH), vol. 8, no. 1 (29), pp. 31–38, 2006, [Online]. Available: https://sid.ir/paper/16467/en

Related Journal Papers