ENHANCEMENT OF PURKINJE NEURONAL EXCITABILITY BY THE INHIBITION OF FAST VOLTAGE GATED K+ CHANNEL FUNCTION IN ATAXIC RATS

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GOUDARZI I.; KAFASHIAN M.R.; JANAHMADI MAHYAR; FATH ELAHI Y.; HAJIZADEH S.

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Journal: Cell Journal (Yakhteh) Year:2008 | Volume:9 | Issue:4 (36) Page(s): 232-239

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Title

ENHANCEMENT OF PURKINJE NEURONAL EXCITABILITY BY THE INHIBITION OF FAST VOLTAGE GATED K+ CHANNEL FUNCTION IN ATAXIC RATS

Author(s)

Keywords

PURKINJE NEURONSQ2

VOLTAGE GATED FAST K+CHANNELSQ2

ATAXIAQ2

CEREBELLUMQ2

INTRACELLULAR RECORDINGQ3

Abstract

Objective: The purpose of this study was to investigate the role of fast inactivating (IA) voltage dependent potassium channels in shaping the discharge activity of cerebellar Purkinje cells (PCs) in ataxic rats.Materials and Methods: Male Sprauge-Dawley rats (40-60g) were used in this study. ATAXIA was induced via single i.p. injection of 3-acethylpyridine (65mg/kg). Four days following induction of ATAXIA, the rats were decapitated after being anesthetized using ether. 300mm thick parasagittal slices were prepared from the vermis of the CEREBELLUM. Sharp INTRACELLULAR RECORDING was achieved from Purkinje cells under continuous superfusion of ACSF containing synaptic blockers.Results: INTRACELLULAR RECORDING of 21 PURKINJE NEURONS in cerebellar slice preparation showed that Purkinje cells of ataxic rats fire in three modes of tonic (23.81%), burst (19.05%) and silence (57.14%). Following the application of 4-AP, 83.33% of the silent PCs were spontaneously fired and the burst activity was robustly enhanced in bursting PCs. In addition, 4-AP significantly increased the duration of burst and active periods but decreased the duration of inactive period. It also increased the number of sodium spikes within each burst.Conclusion: 4-AP sensitive current in Purkinje cell of ataxic rat involves in three modes of firing pattern. In addition, the inhibition of fast inactivating potassium channels (IA) with 4-AP enhances the spontaneous discharge activity of Purkinje cells.

Cites

COMPUTATIONAL INSIGHTS INTO THE NEUROPROTECTIVE ACTION OF RILUZOLE ON 3-ACETYLPYRIDINE-INDUCED ATAXIA IN RATS

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APA: Copy

FATH ELAHI, Y., GOUDARZI, I., HAJIZADEH, S., KAFASHIAN, M.R., & JANAHMADI, MAHYAR. (2008). ENHANCEMENT OF PURKINJE NEURONAL EXCITABILITY BY THE INHIBITION OF FAST VOLTAGE GATED K⁺ CHANNEL FUNCTION IN ATAXIC RATS. CELL JOURNAL (YAKHTEH), 9(4 (36)), 232-239. SID. https://sid.ir/paper/16482/en

Vancouver: Copy

FATH ELAHI Y., GOUDARZI I., HAJIZADEH S., KAFASHIAN M.R., JANAHMADI MAHYAR. ENHANCEMENT OF PURKINJE NEURONAL EXCITABILITY BY THE INHIBITION OF FAST VOLTAGE GATED K⁺ CHANNEL FUNCTION IN ATAXIC RATS. CELL JOURNAL (YAKHTEH)[Internet]. 2008;9(4 (36)):232-239. Available from: https://sid.ir/paper/16482/en

IEEE: Copy

Y. FATH ELAHI, I. GOUDARZI, S. HAJIZADEH, M.R. KAFASHIAN, and MAHYAR JANAHMADI, “ENHANCEMENT OF PURKINJE NEURONAL EXCITABILITY BY THE INHIBITION OF FAST VOLTAGE GATED K⁺ CHANNEL FUNCTION IN ATAXIC RATS,” CELL JOURNAL (YAKHTEH), vol. 9, no. 4 (36), pp. 232–239, 2008, [Online]. Available: https://sid.ir/paper/16482/en

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