COMPARISON THE PROTECTIVE EFFECT OF MUCOSAL BCG VACCINATION WITH SUBCUTANEOUS AGAINST LEISHMANIA MAJOR INFECTION IN SUSCEPTIBLE BALB/C MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SOOUDI S.; ZAVARAN HOSSEINI A.; RAAFATI SIMA; HASHEMI FESHARAKI R.; ESMAEILNIA K.; HASHEMI SEYED MAHMOUD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2007 | Volume:8 | Issue:4 (32) Page(s): 238-245

Download Full-Text

Persian Verion

View:

965

Download:

Cites:

Information Journal Paper

Title

COMPARISON THE PROTECTIVE EFFECT OF MUCOSAL BCG VACCINATION WITH SUBCUTANEOUS AGAINST LEISHMANIA MAJOR INFECTION IN SUSCEPTIBLE BALB/C MICE

Author(s)

Keywords

VACCINATIONQ2

LEISHMANIA MAJORQ2

BCGQ3

RECTALQ2

SUBCUTANEOUSQ2

MUCOSALQ2

Abstract

Introduction: Study the protective effect of MUCOSAL BCG VACCINATION with SUBCUTANEOUS against LEISHMANIA MAJOR infection in susceptible BALB/c miceMaterial and Methods: 6-8 weeks old Male BALB/c mice were divided to two test groups and four control groups of 20 of mice and then vaccinated. Two test groups vaccinated with appropriate dose of BCG through RECTAL and SUBCUTANEOUS routs. They vaccinated one month later with ALM+alum SUBCUTANEOUSly. After receiving the booster dose (21 days later), mice challenged with the injection of 105 LEISHMANIA MAJOR in the hind footpad and lesion development evaluated every week. Immunologic responses like, delayed type hypersensitivity to Purified Protein Derivatives (PPD), splenocytes proliferation and IFN-g and IL-5 cytokine production measured in the supernatant of splenocytes culture. Control groups were those that received only ALM+alum or only alum adjuvant SUBCUTANEOUSly. Another control groups challenged with Leishmania without any VACCINATION or were kept as environmental control without any treatment.Results: stimulatory effect of BCG on immune system observed in both groups of VACCINATION according to significant increase (p£0.05) in delayed type hypersensitivity and IFN-g production response. Increase in splenocytes proliferation observed up to three weeks after challenge. But after that, BCG vaccinated groups had a lot of variations in immune response that finally tend to disease overcome in SUBCUTANEOUSly BCG vaccinated group. The main reason was the significant decrease in IFN-g production and splenocytes proliferation to RECTAL group .Parasite dissemination in lymphoid organs were increased significantly in comparison with RECTAL immunized group. In a different way RECTAL immunized group showed a high resistant to infection by increase and maintenance of anti-leishmania responses.Conclusion: RECTAL BCG VACCINATION can induce more stable cellular immune response in comparison to SUBCUTANEOUS VACCINATION and make animals protective, by inhibition of L. major dissemination.

Cites

No record.

References

No record.

Cite

APA: Copy

SOOUDI, S., ZAVARAN HOSSEINI, A., RAAFATI, SIMA, HASHEMI FESHARAKI, R., ESMAEILNIA, K., & HASHEMI, SEYED MAHMOUD. (2007). COMPARISON THE PROTECTIVE EFFECT OF MUCOSAL BCG VACCINATION WITH SUBCUTANEOUS AGAINST LEISHMANIA MAJOR INFECTION IN SUSCEPTIBLE BALB/C MICE. CELL JOURNAL (YAKHTEH), 8(4 (32)), 238-245. SID. https://sid.ir/paper/16529/en

Vancouver: Copy

SOOUDI S., ZAVARAN HOSSEINI A., RAAFATI SIMA, HASHEMI FESHARAKI R., ESMAEILNIA K., HASHEMI SEYED MAHMOUD. COMPARISON THE PROTECTIVE EFFECT OF MUCOSAL BCG VACCINATION WITH SUBCUTANEOUS AGAINST LEISHMANIA MAJOR INFECTION IN SUSCEPTIBLE BALB/C MICE. CELL JOURNAL (YAKHTEH)[Internet]. 2007;8(4 (32)):238-245. Available from: https://sid.ir/paper/16529/en

IEEE: Copy

S. SOOUDI, A. ZAVARAN HOSSEINI, SIMA RAAFATI, R. HASHEMI FESHARAKI, K. ESMAEILNIA, and SEYED MAHMOUD HASHEMI, “COMPARISON THE PROTECTIVE EFFECT OF MUCOSAL BCG VACCINATION WITH SUBCUTANEOUS AGAINST LEISHMANIA MAJOR INFECTION IN SUSCEPTIBLE BALB/C MICE,” CELL JOURNAL (YAKHTEH), vol. 8, no. 4 (32), pp. 238–245, 2007, [Online]. Available: https://sid.ir/paper/16529/en

Related Journal Papers