Colorimetric Sensor Based on the Interaction of Sildenafil Citrate and Silver Nanoparticles

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Bordbar Maryam; Mohammadmirzaei Atieh

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Journal Paper

Paper Information

Journal: ADVANCES IN ENERGY AND MATERIALS RESEARCH Year:2024 | Volume:1 | Issue:4 Page(s): 4-11

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Information Journal Paper

Title

Colorimetric Sensor Based on the Interaction of Sildenafil Citrate and Silver Nanoparticles

Author(s)

Bordbar Maryam | Mohammadmirzaei Atieh | Issue Writer Certificate

Keywords

Colorimetry

Sildenafil Citrate

Surface Plasmon Resonance

Silver Nanoparticles

Abstract

This study introduces a simple, cost-effective, and highly sensitive colorimetric method for detecting and quantifying Sildenafil Citrate based on the aggregation of citrate-coated silver nanoparticles (AgNPs). The AgNPs were synthesized through the reduction of silver nitrate with sodium borohydride. Under optimized conditions, the presence of Sildenafil Citrate induces a distinct color change in the AgNP solution from light yellow to red, proportional to the Sildenafil Citrate concentration. This aggregation causes a decrease in the localized surface plasmon resonance (LSPR) absorbance at 394 nm and the emergence of a new peak at 530 nm. A linear correlation was established between the Sildenafil Citrate concentration and the absorbance ratio (A530/A394) in the range of 0.34–3.1 µM, with an impressive detection limit of 0.005 µM. The method was successfully applied to quantify Sildenafil Citrate in pharmaceutical tablets, demonstrating high accuracy, excellent stability, and practical applicability for quality control in health products.

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