EXPRESSION OF TWO SURVIVIN VARIANTS IN DIFFERENT DEVELOPMENTAL STAGES OF MOUSE OVARIES

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MAZOUCHI T.; SALEHNIA M.; KHAMEHCHIAN TAHEREH

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Journal: Avicenna Journal of Clinical Medicine Year:2009 | Volume:15 | Issue:4 (SN 50) Page(s): 14-20

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Title

EXPRESSION OF TWO SURVIVIN VARIANTS IN DIFFERENT DEVELOPMENTAL STAGES OF MOUSE OVARIES

Author(s)

MAZOUCHI T. | SALEHNIA M. | KHAMEHCHIAN TAHEREH | Issue Writer Certificate

Keywords

APOPTOSISQ2

FOLLICULAR DEVELOPMENTQ3

OVARYQ3

SURVIVINQ3

Abstract

Introduction & Objective: SURVIVIN is one of the new characterized members of the inhibitor of APOPTOSIS proteins that shows widespread expression in embryonic and tumoric tissues. The aim of this study was to evaluate the expression of SURVIVIN variants in different stages of FOLLICULAR DEVELOPMENT in mouse OVARY. Materials & Methods: This experimental study was carried out on immature female mice (NMRI). Preantral, large preantral and antral follicles were mechanically isolated from ovaries from 12, 16 and 21-day old mice respectively. Total RNA from all above mentioned groups was extracted and cDNA synthesis was done using oligo dt primers and M-MuLV enzyme. PCR amplification of the cDNA samples was done using specific SURVIVIN primers. The semi-quantitative expression of SURVIVIN mRNA in cDNA samples were compared with that of b2m as an internal control, using post-hoc LSD test. Results: Data showed the expression of two SURVIVIN variants (140, 40) in different stages of follicles. The maximum expression of SURVIVIN140 was observed in the preantral follicles and decreased towards antral stage (P<0.05). The level of SURVIVIN 40 did not change significantly in three stages of follicles. The third variant, SURVIVIN 121 mRNA was not expressed in any of follicular stages examined here.Conclusion: Since the highest level of APOPTOSIS is detected in antral follicles, the lowest levels of SURVIVIN140 mRNA in this stage might be related to a possible role in follicular atresia. Further studies at protein level are needed to confirm this role for SURVIVIN 140 in ovarian follicles.

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APA: Copy

MAZOUCHI, T., SALEHNIA, M., & KHAMEHCHIAN, TAHEREH. (2009). EXPRESSION OF TWO SURVIVIN VARIANTS IN DIFFERENT DEVELOPMENTAL STAGES OF MOUSE OVARIES. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 15(4 (SN 50)), 14-20. SID. https://sid.ir/paper/17672/en

Vancouver: Copy

MAZOUCHI T., SALEHNIA M., KHAMEHCHIAN TAHEREH. EXPRESSION OF TWO SURVIVIN VARIANTS IN DIFFERENT DEVELOPMENTAL STAGES OF MOUSE OVARIES. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2009;15(4 (SN 50)):14-20. Available from: https://sid.ir/paper/17672/en

IEEE: Copy

T. MAZOUCHI, M. SALEHNIA, and TAHEREH KHAMEHCHIAN, “EXPRESSION OF TWO SURVIVIN VARIANTS IN DIFFERENT DEVELOPMENTAL STAGES OF MOUSE OVARIES,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 15, no. 4 (SN 50), pp. 14–20, 2009, [Online]. Available: https://sid.ir/paper/17672/en

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