ETHANOLIC EXTRACT CYTOTOXIC EFFECT OF ZINGIBER OFFICINALE IN HEPATOCELLULAR CARCINOMA (HEPG2) CELL LINE

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TAVAKOL AFSHARI J.; MOHEGHI N.; BROUK A.

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Journal: Avicenna Journal of Clinical Medicine Year:2010 | Volume:17 | Issue:3 (SN 57) Page(s): 52-56

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Title

ETHANOLIC EXTRACT CYTOTOXIC EFFECT OF ZINGIBER OFFICINALE IN HEPATOCELLULAR CARCINOMA (HEPG2) CELL LINE

Author(s)

TAVAKOL AFSHARI J. | MOHEGHI N. | BROUK A. | Issue Writer Certificate

Keywords

GINGERQ3

LIVER NEOPLASMSQ2

TOXICITYQ3

Abstract

Introduction & Objective: Hepatocellular carcinoma (HCC, also called malignant hepatoma) is a primary malignancy (cancer) of the liver. Most cases of HCC are secondary to either a viral hepatitic infection (hepatitis B or C) or cirrhosis (alcoholism being the most common cause of hepatic cirrhosis. Recently, the biological activities of zingiber officieale plants have been reported as possessing antitumor, antibacterial, anti ulcer, antifungal, and insecticidal properties. However, the antitumor effects haven't been studied in cancer cell lines. The aim of this study was to investigate the antitumor effect of zingiber officieale on hepatocellular carcinoma cell lines.Materials& Methods: Hepatocellular carcinoma (HEPG2) cell lines and normal connective tissue cell line (L929) were cultured in DMEM medium. Zingiber officinale was extracted and different concentration of zingiber extract (5000 to 78 mg) was added to cell culture. Cell viability was quantitated by MTT assay after 24, 48 and 72 hours.Results: The effects of zingiber officieale on cell viability were observed after 48 hours on cell lines. GINGER doses in concentration 2500 mg inhibited 50% cell growth (IC50) in (HEPG2) cell lines after 48 hours of incubation, respectively.Conclusion: Our study shows that fresh GINGER extract has cytotoxic effects on tumor cells but it doesn't have any cytotoxic effect on normal cells. It seems that GINGER can be considered as a promising chemotherapeutic agent in cancer treatment.

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APA: Copy

TAVAKOL AFSHARI, J., MOHEGHI, N., & BROUK, A.. (2010). ETHANOLIC EXTRACT CYTOTOXIC EFFECT OF ZINGIBER OFFICINALE IN HEPATOCELLULAR CARCINOMA (HEPG2) CELL LINE. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 17(3 (SN 57)), 52-56. SID. https://sid.ir/paper/17723/en

Vancouver: Copy

TAVAKOL AFSHARI J., MOHEGHI N., BROUK A.. ETHANOLIC EXTRACT CYTOTOXIC EFFECT OF ZINGIBER OFFICINALE IN HEPATOCELLULAR CARCINOMA (HEPG2) CELL LINE. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2010;17(3 (SN 57)):52-56. Available from: https://sid.ir/paper/17723/en

IEEE: Copy

J. TAVAKOL AFSHARI, N. MOHEGHI, and A. BROUK, “ETHANOLIC EXTRACT CYTOTOXIC EFFECT OF ZINGIBER OFFICINALE IN HEPATOCELLULAR CARCINOMA (HEPG2) CELL LINE,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 17, no. 3 (SN 57), pp. 52–56, 2010, [Online]. Available: https://sid.ir/paper/17723/en

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