STUDY OF ANTIBIOTIC RESISTANCE PATTERN AND PHENOTYPIC DETECTION OF ESBLS IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED FROM CLINICAL SAMPLES AND DETERMINATION OF MINIMUM INHIBITORY CONCENTRATIONS OF IMIPENEM AND CEFTAZIDIM ANTIBIOTICS

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YOUSEFI MASHOUF R.; ALIJANI P.; SAIDIJAM M.; ALIKHANI M.Y.; RASHIDI H.

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Journal: Avicenna Journal of Clinical Medicine Year:2014 | Volume:20 | Issue:4 (SN 70) Page(s): 295-302

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Title

STUDY OF ANTIBIOTIC RESISTANCE PATTERN AND PHENOTYPIC DETECTION OF ESBLS IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED FROM CLINICAL SAMPLES AND DETERMINATION OF MINIMUM INHIBITORY CONCENTRATIONS OF IMIPENEM AND CEFTAZIDIM ANTIBIOTICS

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Keywords

ANTIBIOTIC RESISTANCEQ2

BETA-LACTAMASESQ2

KLEBSIELLA PNEUMONIAE MINIMAL INHIBITOR CONCENTRATIONQ2

Abstract

Introduction & Objective: One of the mechanisms of ANTIBIOTIC RESISTANCE in gram negative bacteria, particularly Klebsiella pneumonia strains, is the production of Extended-Spectrum b lactamase enzymes (ESBLs). Encoding genes of ESBLs are usually located on the plasmid and they are able to transfer to other gram-negative bacteria. Thus, due to the importance of resistance pattern recognition and its sensitivity to the b-lactam antibiotics, the above mentioned issue was examined in this study.Materials & Methods: In this study different clinical samples of Boroujerd and Hamadan Hospitals during 6 months were collected and identified by biochemical tests and Enterosystem kit. To confirm the strains, the Ure D gene was used as the internal gene of Klebsiella pneumoniae by PCR method. ANTIBIOTIC RESISTANCE by Disk diffusion method was performed. Phenotypic confirmatory test was used to determine the presence of ESBLs. MIC antibiotics of Ceftazidime and imipenem by E test method were determined.Results: The results showed that the highest rate of Klebsiella pneumoniae strains resistance was related to Cefexime antibiotics 46.7%, Ceftriaxone 43.3%, Azthrunam 43.3%, Cefo-axime 41.7%, Cotrimaksazol 40.8% , Ceftazidim 36.7% and the least resistance was related to antibiotics Imipenem 0% Sprofluksasin 16.7%, Cefepime 25% and Gentamicin 26.7%. 56 strains( 46.7%) were identified as ESBL –positive strains. Using E-test strip for Ceftazidim antibiotic, 66 strains were resistant , 10 strains intermediate ,and 44 strains were sensitive to Ceftazidim and by E test method for Imipenem antibiotic ,120 strains were sensitive.Conclusion: The high prevalence of ANTIBIOTIC RESISTANCE and ESBLs production in the cities which were studied indicates the need for screening of ESBLs in clinical samples by laboratory and prescribing appropriate antibiotics with b-lactamase inhibitory power and antibiotics together with clavulanic by physicians.

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بررسی الگوی مقاومت آنتی بیوتیکی سویه های کلبسیلا پنومونیه جداشده از نمونه های ادراری در بیمارستان های آموزشی دانشگاه علوم پزشکی شهید صدوقی یزد

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APA: Copy

YOUSEFI MASHOUF, R., ALIJANI, P., SAIDIJAM, M., ALIKHANI, M.Y., & RASHIDI, H.. (2014). STUDY OF ANTIBIOTIC RESISTANCE PATTERN AND PHENOTYPIC DETECTION OF ESBLS IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED FROM CLINICAL SAMPLES AND DETERMINATION OF MINIMUM INHIBITORY CONCENTRATIONS OF IMIPENEM AND CEFTAZIDIM ANTIBIOTICS. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 20(4 (SN 70)), 295-302. SID. https://sid.ir/paper/17755/en

Vancouver: Copy

YOUSEFI MASHOUF R., ALIJANI P., SAIDIJAM M., ALIKHANI M.Y., RASHIDI H.. STUDY OF ANTIBIOTIC RESISTANCE PATTERN AND PHENOTYPIC DETECTION OF ESBLS IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED FROM CLINICAL SAMPLES AND DETERMINATION OF MINIMUM INHIBITORY CONCENTRATIONS OF IMIPENEM AND CEFTAZIDIM ANTIBIOTICS. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2014;20(4 (SN 70)):295-302. Available from: https://sid.ir/paper/17755/en

IEEE: Copy

R. YOUSEFI MASHOUF, P. ALIJANI, M. SAIDIJAM, M.Y. ALIKHANI, and H. RASHIDI, “STUDY OF ANTIBIOTIC RESISTANCE PATTERN AND PHENOTYPIC DETECTION OF ESBLS IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED FROM CLINICAL SAMPLES AND DETERMINATION OF MINIMUM INHIBITORY CONCENTRATIONS OF IMIPENEM AND CEFTAZIDIM ANTIBIOTICS,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 20, no. 4 (SN 70), pp. 295–302, 2014, [Online]. Available: https://sid.ir/paper/17755/en

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