STUDY OF INTERACTION BETWEEN PREFOLDIN NANO ACTUATOR AND AMYLOID BETA DIMERIC PATHOGENETIC CARGO WITH MD SIMULATION

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KERAMATI MASOUD; HASANZADEH GHASEMI REZA

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Journal: Modares Mechanical Engineering Year:2016 | Volume:16 | Issue:7 Page(s): 385-391

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Title

STUDY OF INTERACTION BETWEEN PREFOLDIN NANO ACTUATOR AND AMYLOID BETA DIMERIC PATHOGENETIC CARGO WITH MD SIMULATION

Author(s)

KERAMATI MASOUD | HASANZADEH GHASEMI REZA | Issue Writer Certificate

Keywords

ALZHEIMER'S DISEASEQ2

AMYLOID BETA OLIGOMERSQ1

MOLECULAR CHAPERONEQ1

PREFOLDIN NANO ACTUATORQ1

MOLECULAR DYNAMICSQ1

Abstract

Alzheimer's is the most common form of dementia. Amyloid beta peptides play a key role in the pathology of ALZHEIMER'S DISEASE and the recent surveys have demonstrated that AMYLOID BETA OLIGOMERS are the most toxic component of them. Among oligomers, considering the high durability of dimer in comparison to other kinds has more toxic effects. Prefoldin is a MOLECULAR CHAPERONE which prevents accumulation of misfolded proteins. Prefoldin has demonstrated that it can also operate as a nano actuator. In this article, the interaction between the PREFOLDIN NANO ACTUATOR and dimeric pathogenic nano cargo in molecular dimensions is investigated; hence all-atom molecular dynamic simulation in explicit solvent was performed at physiological temperature. Visualizing the results and investigating the atomic distance between nano actuator and pathogenic nano cargo revealed that two arms of six arms of PREFOLDIN NANO ACTUATOR have been able to capture cargo and during the simulation they have made hydrogen bonds. Furthermore, investigating the hydrophobic effects between the hydrophobic amino acids in the cargo and nano actuator revealed that these effects have positively affected the stability of the binding between arms and the cargo. This article introduces prefoldin as an inhibitory factor for dimeric oligomer from amyloid beta.

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APA: Copy

KERAMATI, MASOUD, & HASANZADEH GHASEMI, REZA. (2016). STUDY OF INTERACTION BETWEEN PREFOLDIN NANO ACTUATOR AND AMYLOID BETA DIMERIC PATHOGENETIC CARGO WITH MD SIMULATION. MODARES MECHANICAL ENGINEERING, 16(7), 385-391. SID. https://sid.ir/paper/178320/en

Vancouver: Copy

KERAMATI MASOUD, HASANZADEH GHASEMI REZA. STUDY OF INTERACTION BETWEEN PREFOLDIN NANO ACTUATOR AND AMYLOID BETA DIMERIC PATHOGENETIC CARGO WITH MD SIMULATION. MODARES MECHANICAL ENGINEERING[Internet]. 2016;16(7):385-391. Available from: https://sid.ir/paper/178320/en

IEEE: Copy

MASOUD KERAMATI, and REZA HASANZADEH GHASEMI, “STUDY OF INTERACTION BETWEEN PREFOLDIN NANO ACTUATOR AND AMYLOID BETA DIMERIC PATHOGENETIC CARGO WITH MD SIMULATION,” MODARES MECHANICAL ENGINEERING, vol. 16, no. 7, pp. 385–391, 2016, [Online]. Available: https://sid.ir/paper/178320/en

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