COMPARISON BETWEEN PROMETHAZINE AND PLACEBO IN REDUCING POST OPERATIVE NAUSEA AND VOMITING AFTER GENERAL ANESTHESIA FOR CESAREAN SECTION

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DAVOUDI MARYAM; KHOUSHRAFTAR E.

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Journal: Avicenna Journal of Clinical Medicine Year:2006 | Volume:12 | Issue:4 (SN 38) Page(s): 45-48

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Title

COMPARISON BETWEEN PROMETHAZINE AND PLACEBO IN REDUCING POST OPERATIVE NAUSEA AND VOMITING AFTER GENERAL ANESTHESIA FOR CESAREAN SECTION

Author(s)

DAVOUDI MARYAM | KHOUSHRAFTAR E. | Issue Writer Certificate

Keywords

ANESTHESIAQ3

GENERALQ3

CESAREAN SECTIONQ3

NAUSEAQ4

PROMETHAZINEQ3

VOMITINGQ3

Abstract

Introduction & Objective: Post operative NAUSEA and VOMITING are more common in females and pregnant patients. Pregnancy induced changes increases the risk of NAUSEA and VOMITING and aspiration after GENERAL ANESTHESIA. PROMETHAZINE a HI-receptor antagonist is a phenothiazine with prominent antiemetic property. This study was done to determine the effectiveness and side effects of PROMETHAZINE for prevention of post operative NAUSEA and VOMITING in women after GENERAL ANESTHESIA for CESAREAN SECTION.Materials & Methods: The 101 ASA status I or II women undergoing CESAREAN SECTION , were prospectively and randomly allocated to receive either 1 cc PROMETHAZINE (25 mg) (n=51) or 1 cc placebo (n=50) at the induction of ANESTHESIA. Techniques of ANESTHESIA and administered drugs were similar and doses were in the base of body weight in both groups. The occurrence of post operative NAUSEA and VOMITING and use of drug for treatment and probable side effects of PROMETHAZINE were recorded blindly in the recovery room and 12-24 hrs post operative period. Demographic data did not have differences between two groups.Results: The incidence of post operative NAUSEA and VOMITING was identical in two groups and had not meaningful difference. The score of sedation was increased considerably in PROMETHAZINE group (P=0.029).Conclusion: PROMETHAZINE did not significantly decreased post operative NAUSEA and VOMITING versus placebo (P=1, P=0.67).

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APA: Copy

DAVOUDI, MARYAM, & KHOUSHRAFTAR, E.. (2006). COMPARISON BETWEEN PROMETHAZINE AND PLACEBO IN REDUCING POST OPERATIVE NAUSEA AND VOMITING AFTER GENERAL ANESTHESIA FOR CESAREAN SECTION. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 12(4 (SN 38)), 45-48. SID. https://sid.ir/paper/17855/en

Vancouver: Copy

DAVOUDI MARYAM, KHOUSHRAFTAR E.. COMPARISON BETWEEN PROMETHAZINE AND PLACEBO IN REDUCING POST OPERATIVE NAUSEA AND VOMITING AFTER GENERAL ANESTHESIA FOR CESAREAN SECTION. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2006;12(4 (SN 38)):45-48. Available from: https://sid.ir/paper/17855/en

IEEE: Copy

MARYAM DAVOUDI, and E. KHOUSHRAFTAR, “COMPARISON BETWEEN PROMETHAZINE AND PLACEBO IN REDUCING POST OPERATIVE NAUSEA AND VOMITING AFTER GENERAL ANESTHESIA FOR CESAREAN SECTION,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 12, no. 4 (SN 38), pp. 45–48, 2006, [Online]. Available: https://sid.ir/paper/17855/en

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