COMPARISON OF SEQUENTIAL REGIMEN AND STANDARD THERAPY FOR HELICOBACTER PYLORI ERADICATION IN PATIENTS WITH DYSPEPSIA

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KABOLI A.R.; GARMRUDI B.; ROSHANAEI GH.; MAJLESI A.; KHALILIAN A.R.; AGHAJANIMIR M.

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Journal: Avicenna Journal of Clinical Medicine Year:2013 | Volume:20 | Issue:3 (SN 69) Page(s): 184-193

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Title

COMPARISON OF SEQUENTIAL REGIMEN AND STANDARD THERAPY FOR HELICOBACTER PYLORI ERADICATION IN PATIENTS WITH DYSPEPSIA

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Keywords

DRUG THERAPYQ2

DYSPEPSIAQ2

HELICOBACTER PYLORIQ2

Abstract

Introduction & Objective: Some studies have reported successful eradication rates using sequential therapy but more recent studies performed in Asia did not find a similar benefit. Due to inconsistencies in the comparison of standard triple drugs therapy and sequential regimen, in the previous researches we decided to compare these treatments in Persian patients.Materials & Methods: This study is a randomized clinical trial, performed in one hundred and forty patients suffering from DYSPEPSIA with indication for H. pylori eradication between November 2010 and March 2012.Patients were randomized in two equal groups. The patients in the first group (standard) were treated by omeprazole capsule 20 mg BID, amoxicillin capsule 1 gr BID, clarithromycin tablet 500mg BID for 14 days; while the patients in the second group (sequential) were treated by omeprazole capsule 20 mg for 10 days, amoxicillin capsule 1 gr BID for 5 days, then clarithromycin tablet 500 mg and tinidazole tablet 500 mg BID for other 5 days.4-6 weeks after the treatment, we compared the eradication of H.pylori between the two groups by urease breathe test with C14.Results: H. pylori infection was successfully cured in 57/70 (81.43%) with a 10-day sequential therapy, in 60/70 (85.75%) with the standard fourteen-day triple therapy, respectively.Conclusion: We detected no significant differences between the 10-day sequential eradication therapy for H. pylori and 14-day standard triple treatment among the patients.

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APA: Copy

KABOLI, A.R., GARMRUDI, B., ROSHANAEI, GH., MAJLESI, A., KHALILIAN, A.R., & AGHAJANIMIR, M.. (2013). COMPARISON OF SEQUENTIAL REGIMEN AND STANDARD THERAPY FOR HELICOBACTER PYLORI ERADICATION IN PATIENTS WITH DYSPEPSIA. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 20(3 (SN 69)), 184-193. SID. https://sid.ir/paper/17998/en

Vancouver: Copy

KABOLI A.R., GARMRUDI B., ROSHANAEI GH., MAJLESI A., KHALILIAN A.R., AGHAJANIMIR M.. COMPARISON OF SEQUENTIAL REGIMEN AND STANDARD THERAPY FOR HELICOBACTER PYLORI ERADICATION IN PATIENTS WITH DYSPEPSIA. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2013;20(3 (SN 69)):184-193. Available from: https://sid.ir/paper/17998/en

IEEE: Copy

A.R. KABOLI, B. GARMRUDI, GH. ROSHANAEI, A. MAJLESI, A.R. KHALILIAN, and M. AGHAJANIMIR, “COMPARISON OF SEQUENTIAL REGIMEN AND STANDARD THERAPY FOR HELICOBACTER PYLORI ERADICATION IN PATIENTS WITH DYSPEPSIA,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 20, no. 3 (SN 69), pp. 184–193, 2013, [Online]. Available: https://sid.ir/paper/17998/en

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