SYNTHESIS OF NANO-MACRO MAGNESIUM OXIDE BY A FACILE METHOD WITHOUT USING ANY SURFACTANTS AND ITS APPLICATION IN DRUG RELEASE OF NIFEDIPINE

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ABEDI RAD B.; TARLANI A.A.; JAMEH BOZORGHI S.; NIAZI A.

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Journal: Journal of Applied Research in Chemistry Year:2018 | Volume:11 | Issue:4 Page(s): 29-37

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Information Journal Paper

Title

SYNTHESIS OF NANO-MACRO MAGNESIUM OXIDE BY A FACILE METHOD WITHOUT USING ANY SURFACTANTS AND ITS APPLICATION IN DRUG RELEASE OF NIFEDIPINE

Author(s)

ABEDI RAD B. | TARLANI A.A. | JAMEH BOZORGHI S. | NIAZI A. | Issue Writer Certificate

Keywords

MAGNESIUM OXIDEQ1

SUSTAINED-RELEASEQ1

HYDROTHERMALQ1

CUBIC AND SPHERICAL STRUCTURESQ1

NANO-MACRO STRUCTURESQ1

NIFEDIPINEQ1

Abstract

In this study, nano-macro MAGNESIUM OXIDE was synthesized with different structures, such as cube and spherical, by using different ratio arginine and urea as additives without making use of any surfactants by a HYDROTHERMAL method at 130-180oC during 24 hours. Nanoparticles were calcinated at 400oC to obtain particles of sizes between 42 to 80 nm. The samples characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), adsorption and desorption of nitrogen test (BET), infrared spectroscopy (IR), ultraviolet-visible spectroscopy (UV-Vis), and ׳ EDX. NIFEDIPINE, as an insoluble drug, was loaded on MAGNESIUM OXIDE substrate (sample MgO1 and MgO2). The in vitro drug release was investigated in simulated intestinal fluid (pH = 6.8) and simulated gastric fluid (pH = 1.2). At the simulated intestinal fluid (pH = 6.8), the amount of drug release enhanced to 100% for sample MgO2 (cubic structure) after15 hours. The Korsmeyer– and MgO2. ׳ Peppas models were applied to evaluate the kinetics of NIFEDIPINE release from MgO1 The results showed that the kinetic of the drug release was non-ficken in both SGF and SIF.

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APA: Copy

ABEDI RAD, B., TARLANI, A.A., JAMEH BOZORGHI, S., & NIAZI, A.. (2018). SYNTHESIS OF NANO-MACRO MAGNESIUM OXIDE BY A FACILE METHOD WITHOUT USING ANY SURFACTANTS AND ITS APPLICATION IN DRUG RELEASE OF NIFEDIPINE. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 11(4 ), 29-37. SID. https://sid.ir/paper/179999/en

Vancouver: Copy

ABEDI RAD B., TARLANI A.A., JAMEH BOZORGHI S., NIAZI A.. SYNTHESIS OF NANO-MACRO MAGNESIUM OXIDE BY A FACILE METHOD WITHOUT USING ANY SURFACTANTS AND ITS APPLICATION IN DRUG RELEASE OF NIFEDIPINE. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2018;11(4 ):29-37. Available from: https://sid.ir/paper/179999/en

IEEE: Copy

B. ABEDI RAD, A.A. TARLANI, S. JAMEH BOZORGHI, and A. NIAZI, “SYNTHESIS OF NANO-MACRO MAGNESIUM OXIDE BY A FACILE METHOD WITHOUT USING ANY SURFACTANTS AND ITS APPLICATION IN DRUG RELEASE OF NIFEDIPINE,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 11, no. 4 , pp. 29–37, 2018, [Online]. Available: https://sid.ir/paper/179999/en

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