INVESTIGATION OF THE INTERACTION BETWEEN 2, 2'-BIPYRIDINEHEXYLGLYCINATOPALL ADIUM (II) NITRATE ANTITUMOR COMPLEX AND SERUM ALBUMIN

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MANSOURI TORSHIZI H.; JAHANGIRY S.; ISLAMI MOGHADAM M.; SAIDIFAR M.; HEYDARI A.

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Journal: Journal of Applied Research in Chemistry Year:2017 | Volume:11 | Issue:2 Page(s): 79-88

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Title

INVESTIGATION OF THE INTERACTION BETWEEN 2, 2'-BIPYRIDINEHEXYLGLYCINATOPALL ADIUM (II) NITRATE ANTITUMOR COMPLEX AND SERUM ALBUMIN

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PALLADIUM (II) COMPLEXQ1

BOVINE SERUM ALBUMINQ1

BINDING PARAMETERSQ1

THERMODYNAMIC PARAMETERSQ2

Abstract

A new antitumor complex, “2, 2'-bipyridinehexylglycinatopalladium (II) nitrate”, has been synthesized by reaction between diaqu-2, 2'-bipyridinepalladium (II) nitrate and sodium salt of hexylglycinate. This complex has been characterized by conductivity measurement, elemental analysis and spectroscopic methods like FT-IR, 1H-NMR and UV-Vis. Interaction of this complex with BOVINE SERUM ALBUMIN (BSA) at pH=7 has been carried out using UV-Vis spectrophotometry at 310 and 320 K and microcalorimetry at 320 K. This complex can denature the protein with positive cooperatively in binding (interaction of a molecule with BSA facilitate the interaction of second molecule) and its concentration in the midpoint of transition from native to denature, L1.2, 0.3 and 0.26 mM at 310 and 320 K, is quite low. In these studies, BINDING PARAMETERS: g (number of binding sites per BSA molecul equals 18), Kapp (apparent binding constant) 31.5 and 28.9 (mmol/L)-1, n (Hill coefficient, showing cooperativity of the system) are 1.2 and 1.3, and m (a measure of the metal complex strength for BSA denaturation) are 60.24 and 68.32 kJ/mol were found at 310 and 320 K, respectively. THERMODYNAMIC PARAMETERS: DGo(H2O)0 (conformational stability of BSA in absence of metal complex) -21.247 (at 310 K) and -26.787 (at 320 K) kJ/mol and DHo(H2O)0 kJ/mol (enthalpy of BSA denaturation by the metal complex between 310 and 320 K) have been determined -174.315.

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APA: Copy

MANSOURI TORSHIZI, H., JAHANGIRY, S., ISLAMI MOGHADAM, M., SAIDIFAR, M., & HEYDARI, A.. (2017). INVESTIGATION OF THE INTERACTION BETWEEN 2, 2'-BIPYRIDINEHEXYLGLYCINATOPALL ADIUM (II) NITRATE ANTITUMOR COMPLEX AND SERUM ALBUMIN. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 11(2 ), 79-88. SID. https://sid.ir/paper/180086/en

Vancouver: Copy

MANSOURI TORSHIZI H., JAHANGIRY S., ISLAMI MOGHADAM M., SAIDIFAR M., HEYDARI A.. INVESTIGATION OF THE INTERACTION BETWEEN 2, 2'-BIPYRIDINEHEXYLGLYCINATOPALL ADIUM (II) NITRATE ANTITUMOR COMPLEX AND SERUM ALBUMIN. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2017;11(2 ):79-88. Available from: https://sid.ir/paper/180086/en

IEEE: Copy

H. MANSOURI TORSHIZI, S. JAHANGIRY, M. ISLAMI MOGHADAM, M. SAIDIFAR, and A. HEYDARI, “INVESTIGATION OF THE INTERACTION BETWEEN 2, 2'-BIPYRIDINEHEXYLGLYCINATOPALL ADIUM (II) NITRATE ANTITUMOR COMPLEX AND SERUM ALBUMIN,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 11, no. 2 , pp. 79–88, 2017, [Online]. Available: https://sid.ir/paper/180086/en

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