A STRUCTURAL STUDY ON THE INTERACTION OF THE ANTI-CANCER COMPOUND OF PLATINUM COMPLEX WITH HUMAN SERUM ALBUMIN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NOORIZADEH SARA; DIVSALAR ADELEH; ESLAMI MOGHADDAM MAHBUBEH; SABOURY ALI AKBAR

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: NOVA BIOLOGICA REPERTA Year:2016 | Volume:2 | Issue:4 Page(s): 250-259

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,010

Download:

Cites:

Information Journal Paper

Title

A STRUCTURAL STUDY ON THE INTERACTION OF THE ANTI-CANCER COMPOUND OF PLATINUM COMPLEX WITH HUMAN SERUM ALBUMIN

Author(s)

NOORIZADEH SARA | DIVSALAR ADELEH | ESLAMI MOGHADDAM MAHBUBEH | SABOURY ALI AKBAR | Issue Writer Certificate

Keywords

HSAQ2

PLATINUM COMPLEXQ2

FLUORESCENCEQ1

SIDE EFFECTSQ2

THERMODYNAMIC PARAMETERSQ2

Abstract

Human serum albumin (HSA) is the most abundant protein in blood plasma, which is responsible for 80% of blood pressure; it also acts as a carrier protein for many compounds in the blood such as drugs. In the present study, the interaction and side-effects of a newly-designed anti-cancer compound of isopentyl-glycine1, 10-phenanthroline Platinum nitrate on HSA have been investigated. In this investigation, the SIDE EFFECTS, values of the number of binding sites and the association binding constants of new synthesized Pt(II) complex have been studied by different spectroscopic (fluorescence and circular diachronic (CD) techniques at different temperatures of 25 and 37oC. The analysis of FLUORESCENCE spectra showed that the addition of the complex led to a significant reduction in the FLUORESCENCE spectra of HSA via quenching mechanism. Also, it can change the three-dimensional structure of tryptophan existing in the protein. The number of binding sites, the Stern-Volmer quenching constant and the association constant of the complex were calculated on the HSA protein. The analysis of circular dichroic spectra showed that the complex can change the regular secondary structure of the protein via reduction of α helical structure and increase of b sheet structure which indicates a decrease in the stability of the protein. According to the results obtained, it can be concluded that this new synthesized Pt(II) complex can bind to the main blood carrier protein (HSA) and change the secondary and tertiary structure of the protein which can be considered as the side-effects of this drug.

Cites

No record.

References

No record.

Cite

APA: Copy

NOORIZADEH, SARA, DIVSALAR, ADELEH, ESLAMI MOGHADDAM, MAHBUBEH, & SABOURY, ALI AKBAR. (2016). A STRUCTURAL STUDY ON THE INTERACTION OF THE ANTI-CANCER COMPOUND OF PLATINUM COMPLEX WITH HUMAN SERUM ALBUMIN. NOVA BIOLOGICA REPERTA, 2(4), 250-259. SID. https://sid.ir/paper/250566/en

Vancouver: Copy

NOORIZADEH SARA, DIVSALAR ADELEH, ESLAMI MOGHADDAM MAHBUBEH, SABOURY ALI AKBAR. A STRUCTURAL STUDY ON THE INTERACTION OF THE ANTI-CANCER COMPOUND OF PLATINUM COMPLEX WITH HUMAN SERUM ALBUMIN. NOVA BIOLOGICA REPERTA[Internet]. 2016;2(4):250-259. Available from: https://sid.ir/paper/250566/en

IEEE: Copy

SARA NOORIZADEH, ADELEH DIVSALAR, MAHBUBEH ESLAMI MOGHADDAM, and ALI AKBAR SABOURY, “A STRUCTURAL STUDY ON THE INTERACTION OF THE ANTI-CANCER COMPOUND OF PLATINUM COMPLEX WITH HUMAN SERUM ALBUMIN,” NOVA BIOLOGICA REPERTA, vol. 2, no. 4, pp. 250–259, 2016, [Online]. Available: https://sid.ir/paper/250566/en

Related Journal Papers