DETECTION OF EXTENDED-SPECTRUM BETA-LACTAMASE PRODUCTION IN CLINICAL ISOLATES OF ESCHERICHIA COLI BASED ON MICS OF CEFTAZIDIME, CEFTRIAXON AND CEFEPIM

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MIRZAEI MOHSEN; CHITSAZ MOHSEN; MANSOURI SADEGH

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Researcher Bulletin of Medical Sciences Year:2008 | Volume:13 | Issue:4 (64) Page(s): 335-345

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

985

Download:

Cites:

Information Journal Paper

Title

DETECTION OF EXTENDED-SPECTRUM BETA-LACTAMASE PRODUCTION IN CLINICAL ISOLATES OF ESCHERICHIA COLI BASED ON MICS OF CEFTAZIDIME, CEFTRIAXON AND CEFEPIM

Author(s)

MIRZAEI MOHSEN | CHITSAZ MOHSEN | MANSOURI SADEGH | Issue Writer Certificate

Keywords

ESCHERISHIA COLIQ2

ESBLSQ2

THIRD GENERATION CEPHALOSPORINQ3

Abstract

Background: Extended-Spectrum b-lactamases (ESBLs) are plasmid-mediated enzymes that hydrolyze the oxyimino β-lactam substance such as third-generation Cephalosporins (Ceftazidim, Ceftriaxone, Cefotaxime). Presence of ESBL-producing organisms results in decrease in efficacy of extended-spectrum Cephalosporines in treatment of serious clinical infections caused by these organisms. So the treatment options are limited and failure treatment and antibiotic resistance are the consequence of inadequate options.Materials and Methods: A total of 160 isolates of Escherichia coli were collected from clinical samples of three hospitals in Tehran. MICs for Ceftriaxone, Ceftazidim and Cefepime were determined by standard agar dilution method. A MIC above 1 mg/L to any of these three was subjected to confirmatory testing as per CLSI method.Results: Primary phenotypic tests revealed that 56.68% (n=89) of E.coli isolates produced extended-spectrum beta-lactamases. Using of clavulanic acid in confirmatory tests, ESBL production was confirmed in 96.7% (n=86) of isolates with primary positive phenotype. The presence of an ESBL was not confirmed in 3.3% (n=3) of the screen positive isolates.Conclusion: This study showed that ESBL productions in clinical isolates of E. coli in Tehran city's university hospitals were extremely high and it is suggested detection of ESBLS as routine tests in order to increase the effectiveness of treatment.

Cites

No record.

References

Cite

APA: Copy

MIRZAEI, MOHSEN, CHITSAZ, MOHSEN, & MANSOURI, SADEGH. (2008). DETECTION OF EXTENDED-SPECTRUM BETA-LACTAMASE PRODUCTION IN CLINICAL ISOLATES OF ESCHERICHIA COLI BASED ON MICS OF CEFTAZIDIME, CEFTRIAXON AND CEFEPIM. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 13(4 (64)), 335-345. SID. https://sid.ir/paper/18116/en

Vancouver: Copy

MIRZAEI MOHSEN, CHITSAZ MOHSEN, MANSOURI SADEGH. DETECTION OF EXTENDED-SPECTRUM BETA-LACTAMASE PRODUCTION IN CLINICAL ISOLATES OF ESCHERICHIA COLI BASED ON MICS OF CEFTAZIDIME, CEFTRIAXON AND CEFEPIM. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2008;13(4 (64)):335-345. Available from: https://sid.ir/paper/18116/en

IEEE: Copy

MOHSEN MIRZAEI, MOHSEN CHITSAZ, and SADEGH MANSOURI, “DETECTION OF EXTENDED-SPECTRUM BETA-LACTAMASE PRODUCTION IN CLINICAL ISOLATES OF ESCHERICHIA COLI BASED ON MICS OF CEFTAZIDIME, CEFTRIAXON AND CEFEPIM,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 13, no. 4 (64), pp. 335–345, 2008, [Online]. Available: https://sid.ir/paper/18116/en

Related Journal Papers