DIAGNOSTIC ROLE OF ESR, CRP, LEUKOCYTOSIS AND NEUTROPHIL/ LYMPHOCYTE IN PERIPHERAL BLOOD SMEAR IN CHILDREN UNDER 14 WITH ACUTE APPENDICITIS

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ROUZROKH MOHSEN; EBRAHEIMI FARD FARZANEH; MOMENI NASERADIN; TAVASSOLI AZITA; A GORGI FATEMEH

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Journal: Researcher Bulletin of Medical Sciences Year:2011 | Volume:16 | Issue:1 (79) Page(s): 42-46

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Title

DIAGNOSTIC ROLE OF ESR, CRP, LEUKOCYTOSIS AND NEUTROPHIL/ LYMPHOCYTE IN PERIPHERAL BLOOD SMEAR IN CHILDREN UNDER 14 WITH ACUTE APPENDICITIS

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Keywords

APPENDICITISQ3

DIAGNOSISQ3

CHILDQ3

LEUKOCYTE COUNTQ3

C-REACTIVE PROTEINQ3

Abstract

Background and Aim: Clinical assessment outweighs the use of paraclinical investigations in the DIAGNOSIS of acute APPENDICITIS. Few studies have addressed the predictive value of white blood cells (WBCs) and C-REACTIVE PROTEIN (CRP) at different cut-off values in APPENDICITIS. Our purpose was to determine the predictive value of WBC count, CRP, ESR and neutrophil to lymphocyte ratio in pediatric APPENDICITIS. Materials and methods: WBC count, CRP, ESR and neutrophil to lymphocyte ratio were measured prospectively in 307 patients presenting with lower abdominal pain who underwent surgical exploration; the results were correlated with each patient's outcome. Gold standard for diagnosing APPENDICITIS was based on histopathologic evaluation. Results: Patients (189 boys, 118 girls) were 1-14 years old (mean 7.9±2.9 years). Overall WBC count had the highest sensitivity in the prediction of DIAGNOSIS of APPENDICITIS (86.8%), whereas sensitivity of CRP was 76%. ESR and neutrophil to lymphocyte ratio revealed a modest sensitivity. Combining the diagnostic tests increased the sensitivity significantly. Sensitivity increased to 96.1% when CRP and WBC count were used together while it was 99.1% when the combination of all diagnostic tests were used. Conclusion: This result may have important clinical and economic implications. We suggest that patients experiencing lower abdominal pain, with normal WBC count and CRP values, are unlikely to have acute APPENDICITIS and can be safely observed for a longer time.

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APA: Copy

ROUZROKH, MOHSEN, EBRAHEIMI FARD, FARZANEH, MOMENI, NASERADIN, TAVASSOLI, AZITA, & A GORGI, FATEMEH. (2011). DIAGNOSTIC ROLE OF ESR, CRP, LEUKOCYTOSIS AND NEUTROPHIL/ LYMPHOCYTE IN PERIPHERAL BLOOD SMEAR IN CHILDREN UNDER 14 WITH ACUTE APPENDICITIS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 16(1 (79)), 42-46. SID. https://sid.ir/paper/18138/en

Vancouver: Copy

ROUZROKH MOHSEN, EBRAHEIMI FARD FARZANEH, MOMENI NASERADIN, TAVASSOLI AZITA, A GORGI FATEMEH. DIAGNOSTIC ROLE OF ESR, CRP, LEUKOCYTOSIS AND NEUTROPHIL/ LYMPHOCYTE IN PERIPHERAL BLOOD SMEAR IN CHILDREN UNDER 14 WITH ACUTE APPENDICITIS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2011;16(1 (79)):42-46. Available from: https://sid.ir/paper/18138/en

IEEE: Copy

MOHSEN ROUZROKH, FARZANEH EBRAHEIMI FARD, NASERADIN MOMENI, AZITA TAVASSOLI, and FATEMEH A GORGI, “DIAGNOSTIC ROLE OF ESR, CRP, LEUKOCYTOSIS AND NEUTROPHIL/ LYMPHOCYTE IN PERIPHERAL BLOOD SMEAR IN CHILDREN UNDER 14 WITH ACUTE APPENDICITIS,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 16, no. 1 (79), pp. 42–46, 2011, [Online]. Available: https://sid.ir/paper/18138/en

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