CORRELATION BETWEEN STAGING OF HEPATIC FIBROSIS AND BIOCHEMICAL MARKERS IN PATIENT WITH LIVER FIBROSIS

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SHOKOUHI SH.; RAKHSHAN M.; GACHKAR L.; KHALAJ E.

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Journal: Researcher Bulletin of Medical Sciences Year:2008 | Volume:13 | Issue:2 (62) Page(s): 89-97

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Title

CORRELATION BETWEEN STAGING OF HEPATIC FIBROSIS AND BIOCHEMICAL MARKERS IN PATIENT WITH LIVER FIBROSIS

Author(s)

SHOKOUHI SH. | RAKHSHAN M. | GACHKAR L. | KHALAJ E. | Issue Writer Certificate

Keywords

FIBROSISQ3

BIOCHEMICAL MARKERSQ3

CIRRHOSISQ3

PLATELETQ3

ASTQ3

ALBUMINQ2

Abstract

Background: Liver FIBROSIS is an inevitable result of chronic liver diseases which may ultimately lead into liver CIRRHOSIS. Diagnosis and grading of liver FIBROSIS is of considerable importance in treatment strategy, treatment response, prognosis and potential risk factors for the disease complications. Although liver biopsy is the best known technique for evaluation of liver FIBROSIS, researchers have been searching for a more appropriate alternative to be used instead due to its harsh nature along with several side effects. One of the suggested ones is the use of BIOCHEMICAL MARKERS. Our aim in this study, therefore, was the assessment of some of these BIOCHEMICAL MARKERS.Materials and Methods: In a retrospective trial, 130 patients (94 men (72.3%) and 36 women (27.7%)) of whom had undergone liver biopsy, were studied. Former biopsy samples were reviewed. Gathered data from their medical file and pathology reports were analyzed by SPSS 11.5.Results: It was revealed that there was a positive correlation between age and severity FIBROSIS. There was no significant relationship between liver FIBROSIS and gender. Comparing the patients with liver FIBROSIS and non-fibrotic ones, we found that the AST/platelet index is an appropriate marker for distinction of these patients. To distinguish the patients without liver FIBROSIS from ones with moderate liver FIBROSIS, a cutoff point=0.39, PPV=0.7& NPV=0.54 was obtained, whereas for differentiating them from severe liver FIBROSIS patients, the cutoff point of 0.25, PPV=0.76 & NPV=0.7 was achieved. Distancing the mild and moderate FIBROSIS, PLATELET was found to be an appropriate variable, having a cut off point of 158500.Moreover, to set mild and sever FIBROSIS apart, PLATELET and ALBUMIN were more valuable. In this study cut off point of 151000 for PLATELET and 3.6 for ALBUMIN was obtained, respectively. Similar to other relevant studies we also could not find any appropriate marker for making the distinction between moderate and severe FIBROSIS.Conclusion: Our study outlines that AST/platelet index has an appropriate cut off point for distinction between on-fibrotic and moderate and sever liver FIBROSIS. Distinguishing the mild cases from both moderate and sever FIBROSIS, PLATELET is a good marker. Furthermore, ALBUMIN is another marker for distinction between mild and sever FIBROSIS. The studied markers are not able to distinct all stages of FIBROSIS. Due to their limitations, they cannot be applied in various clinical situations.In this regard, no demote substitute for liver biopsy has been found yet. Acquiring a test or technique that contains all necessary standards for evaluation of liver FIBROSIS requires further studies and researches.

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APA: Copy

SHOKOUHI, SH., RAKHSHAN, M., GACHKAR, L., & KHALAJ, E.. (2008). CORRELATION BETWEEN STAGING OF HEPATIC FIBROSIS AND BIOCHEMICAL MARKERS IN PATIENT WITH LIVER FIBROSIS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 13(2 (62)), 89-97. SID. https://sid.ir/paper/18178/en

Vancouver: Copy

SHOKOUHI SH., RAKHSHAN M., GACHKAR L., KHALAJ E.. CORRELATION BETWEEN STAGING OF HEPATIC FIBROSIS AND BIOCHEMICAL MARKERS IN PATIENT WITH LIVER FIBROSIS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2008;13(2 (62)):89-97. Available from: https://sid.ir/paper/18178/en

IEEE: Copy

SH. SHOKOUHI, M. RAKHSHAN, L. GACHKAR, and E. KHALAJ, “CORRELATION BETWEEN STAGING OF HEPATIC FIBROSIS AND BIOCHEMICAL MARKERS IN PATIENT WITH LIVER FIBROSIS,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 13, no. 2 (62), pp. 89–97, 2008, [Online]. Available: https://sid.ir/paper/18178/en

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