EFFECTS OF LEUKOCYTE-DEPLETION FILTERS ON ALLUIMUNIZATION DERIVED REACTIONS OF PLATELET TRANSFUSION IN ACUTE LEUKEMIC PATIENTS

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HAJFATH ALI A.; ILKHANI M.; AZARGASHB E.A.; SHAMS HOSSEIN; RAZIAN A.; ESFAHANI FATEMEH

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Journal: Researcher Bulletin of Medical Sciences Year:2008 | Volume:13 | Issue:2 (62) Page(s): 155-158

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Title

EFFECTS OF LEUKOCYTE-DEPLETION FILTERS ON ALLUIMUNIZATION DERIVED REACTIONS OF PLATELET TRANSFUSION IN ACUTE LEUKEMIC PATIENTS

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Keywords

LEUKMIAQ3

ALLUIMUNIZATIONQ3

LEUKOCYTE DEPLETION FILTERSQ3

Abstract

Background: Leukemia is the most common malignancy among adults and children which may develop several side affects such as anemia, infection and thrombocytopnia-related hemorrage. Many modalities have been suggested for prevention of Alloimunization and one of them is using of leukocytes free products. In fact, platelets could not solely stimulate immune reaction. This study is conducted at two hospials of "Shohada" and" Taleghani" to demonstrate the usefulness of such products.Materials and Methods: This research is a single- blinded clinical trial. All the patients had acute leukemia. In control group (24 subjects) we used a routin infusion set for transfusion and in experimental group (20 subjects) a beefeater was applied during the transfusion. Platelet was counted one hour and 24 hr after transfusion. CCI formulate was used to represent a signs for Alluimunization. If CCI was less than lOx10 L/M2 after transfusion or it became below 5-7x 10 L/M2 after 18-24hr, the subject was considered alhtimmune.Results: After one hour, 21 cases out of 24 were alluimmuned in control group whereas in experimental group 13 cases from 20 patients became alluimmune. After 24 hours, 5 cases in control group and 5 ones in experiments were found to be Alluimmune. Conclusion: we did not prove any preventive properties from leukocyte-depletion filters in reducing the risk factors of ALLUIMUNIZATION amongst patients with acute leukemia.

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APA: Copy

HAJFATH ALI, A., ILKHANI, M., AZARGASHB, E.A., SHAMS, HOSSEIN, RAZIAN, A., & ESFAHANI, FATEMEH. (2008). EFFECTS OF LEUKOCYTE-DEPLETION FILTERS ON ALLUIMUNIZATION DERIVED REACTIONS OF PLATELET TRANSFUSION IN ACUTE LEUKEMIC PATIENTS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 13(2 (62)), 155-158. SID. https://sid.ir/paper/18179/en

Vancouver: Copy

HAJFATH ALI A., ILKHANI M., AZARGASHB E.A., SHAMS HOSSEIN, RAZIAN A., ESFAHANI FATEMEH. EFFECTS OF LEUKOCYTE-DEPLETION FILTERS ON ALLUIMUNIZATION DERIVED REACTIONS OF PLATELET TRANSFUSION IN ACUTE LEUKEMIC PATIENTS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2008;13(2 (62)):155-158. Available from: https://sid.ir/paper/18179/en

IEEE: Copy

A. HAJFATH ALI, M. ILKHANI, E.A. AZARGASHB, HOSSEIN SHAMS, A. RAZIAN, and FATEMEH ESFAHANI, “EFFECTS OF LEUKOCYTE-DEPLETION FILTERS ON ALLUIMUNIZATION DERIVED REACTIONS OF PLATELET TRANSFUSION IN ACUTE LEUKEMIC PATIENTS,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 13, no. 2 (62), pp. 155–158, 2008, [Online]. Available: https://sid.ir/paper/18179/en

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