COMPARISON OF EFFICACY OF EPINEPHRINE INJECTION ALONE AND PLUS ARGON PLASMA COAGULATION IN BLEEDING PEPTIC ULCERS

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EHSANI ARDAKANI M.J.; RAMBOD M.; MOHAMMAD MAKI S.S.; ADIBI P.

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Journal: Researcher Bulletin of Medical Sciences Year:2007 | Volume:11 | Issue:6 (54) Page(s): 351-356

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Title

COMPARISON OF EFFICACY OF EPINEPHRINE INJECTION ALONE AND PLUS ARGON PLASMA COAGULATION IN BLEEDING PEPTIC ULCERS

Author(s)

EHSANI ARDAKANI M.J. | RAMBOD M. | MOHAMMAD MAKI S.S. | ADIBI P. | Issue Writer Certificate

Keywords

ARGON PLASMA COAGULATIONQ3

UPPER GASTROINTESTINAL BLEEDINGQ3

REBLEEDINGQ3

ENDOSCOPYQ3

EPINEPHRINEQ3

Abstract

Background: Considering the prevalence of peptic ulcers and their complications and also existence of discrepancies about the effect of EPINEPHRINE injection with and without ARGON PLASMA COAGULATION (APC) and lack of any report in our country, this investigation was carried out in Taleghani hospital in 2004.Materials and Methods: In this clinical trial, 60 consecutive patients with bleeding peptic ulcers were treated by combination of APC plus EPINEPHRINE injection (26 Cases) or EPINEPHRINE injection alone (34 Controls). Patients with malignant ulcer, contact bleeding and adhesive clot, renal insufficiency and coagulopathy, recent consumption of NSAIDs, hemodynamic instability and history of upper gastrointestinal surgery were excluded. REBLEEDING rate (fresh blood or coffee ground materials in emesis or nasogastric tube or melena or both) and decreasing hemoglobin at least 2 gr/dl in 24 hour were analyzed using Fisher's exact test, Chi square test, independent sample T-Test and Mann-Witney test. P<0.05 was considered significant.Results: The two groups were similar in age, sex, hemodynamic state, location, type and greater dimension of ulcer. REBLEEDING rates in cases and controls were 7.7% and 20.6% , respectively (P<0.3). Of course, the relative risk of REBLEEDING among controls was 2.68 times greater than cases. The cases and controlshad no statistically differences in need for surgery (3.8%vs. 11.8%), units of transfused packed cell (4±2.6vs. 3±2.9), days of hospitalization (7.9±7.4vs. 5.7±3) and mortality rate (3.8%vs. 5.9%).Conclusions: Injection of EPINEPHRINE plus APC has no effect on bleeding peptic ulcer. It seems that repeating the study with proper sample size will clarify the level of differences correctly.

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APA: Copy

EHSANI ARDAKANI, M.J., RAMBOD, M., MOHAMMAD MAKI, S.S., & ADIBI, P.. (2007). COMPARISON OF EFFICACY OF EPINEPHRINE INJECTION ALONE AND PLUS ARGON PLASMA COAGULATION IN BLEEDING PEPTIC ULCERS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 11(6 (54)), 351-356. SID. https://sid.ir/paper/18197/en

Vancouver: Copy

EHSANI ARDAKANI M.J., RAMBOD M., MOHAMMAD MAKI S.S., ADIBI P.. COMPARISON OF EFFICACY OF EPINEPHRINE INJECTION ALONE AND PLUS ARGON PLASMA COAGULATION IN BLEEDING PEPTIC ULCERS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2007;11(6 (54)):351-356. Available from: https://sid.ir/paper/18197/en

IEEE: Copy

M.J. EHSANI ARDAKANI, M. RAMBOD, S.S. MOHAMMAD MAKI, and P. ADIBI, “COMPARISON OF EFFICACY OF EPINEPHRINE INJECTION ALONE AND PLUS ARGON PLASMA COAGULATION IN BLEEDING PEPTIC ULCERS,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 11, no. 6 (54), pp. 351–356, 2007, [Online]. Available: https://sid.ir/paper/18197/en

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