BENZYDAMINE FOR PROPHYLAXIS OF RADIATION-INDUCED ORAL MUCOSITIS IN HEAD AND NECK CANCERS; A DOUBLE-BLIND CLINICAL TRIAL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KAMIAN SH.; KAZEMIAN A.; AGHILI M.; AMOUZGAR HASHEMI F.; HADAD P.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Researcher Bulletin of Medical Sciences Year:2008 | Volume:13 | Issue:3 (63) Page(s): 183-191

Download Full-Text

Persian Verion

View:

1,268

Download:

Cites:

Information Journal Paper

Title

BENZYDAMINE FOR PROPHYLAXIS OF RADIATION-INDUCED ORAL MUCOSITIS IN HEAD AND NECK CANCERS; A DOUBLE-BLIND CLINICAL TRIAL

Author(s)

Keywords

BENZYDAMINEQ3

MUCOSITISQ3

HEAD AND NECK TUMORSQ3

Abstract

Background: This study has been conducted to determine the effect of using oral rinse BENZYDAMINE in prevention of radiation induced MUCOSITIS.Materials and Methods: Patients with head and neck cancers, who referred to Cancer Institute between 2004 and 2005, were enrolled in a double blind clinical trail. They had to receive 15 cc of oral rinse BENZYDAMINE or placebo, four times a day, from the first day of radiotherapy up to the end of the course. The incidence of MUCOSITIS grade 3 or more was evaluated.Results: From 100 patients who were randomized in this trail, 19patients were excluded of the analysis due to minor side-effects of drug, or stopping the radiotherapy. The incidence of MUCOSITIS grade 3 or more was 43.6% among 39 cases in treated group, whereas among 42 cases in placebo group this rate was 78.6 %. The difference was, therefore, significant (P< 0.005). MUCOSITIS grade 3 or more was 1.8 times more frequent in placebo group (Relative Risk=I.8). Also, if the patients did not receive BENZYDAMINE the attributive risk of MUCOSITIS was 35%. After the third week of treatment, the mean grade of MUCOSITIS was more than 2 in the placebo group; but in the BENZYDAMINE group it was less than 2 up to the end of radiotherapy (P<0.001).Conclusion: According to these results it seems that oral rinse BENZYDAMINEis effective, safe, and well-tolerated for prophylactic treatment of radiation-induced oral MUCOSITIS in HEAD AND NECK TUMORS. There is a need to evaluate the efficacy of BENZYDAMINEin another large study in Iran.

Cites

بررسی تاثیر دهان شویه با اسانس نعناع در پیشگیری از موکوزیت دهانی ناشی از شیمی درمانی

References

No record.

Cite

APA: Copy

KAMIAN, SH., KAZEMIAN, A., AGHILI, M., AMOUZGAR HASHEMI, F., & HADAD, P.. (2008). BENZYDAMINE FOR PROPHYLAXIS OF RADIATION-INDUCED ORAL MUCOSITIS IN HEAD AND NECK CANCERS; A DOUBLE-BLIND CLINICAL TRIAL. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 13(3 (63)), 183-191. SID. https://sid.ir/paper/18214/en

Vancouver: Copy

KAMIAN SH., KAZEMIAN A., AGHILI M., AMOUZGAR HASHEMI F., HADAD P.. BENZYDAMINE FOR PROPHYLAXIS OF RADIATION-INDUCED ORAL MUCOSITIS IN HEAD AND NECK CANCERS; A DOUBLE-BLIND CLINICAL TRIAL. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2008;13(3 (63)):183-191. Available from: https://sid.ir/paper/18214/en

IEEE: Copy

SH. KAMIAN, A. KAZEMIAN, M. AGHILI, F. AMOUZGAR HASHEMI, and P. HADAD, “BENZYDAMINE FOR PROPHYLAXIS OF RADIATION-INDUCED ORAL MUCOSITIS IN HEAD AND NECK CANCERS; A DOUBLE-BLIND CLINICAL TRIAL,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 13, no. 3 (63), pp. 183–191, 2008, [Online]. Available: https://sid.ir/paper/18214/en

Related Journal Papers